2,3,5,6-Tetrafluoro-[N-(3-aminopropyl)-ε-caprolactam]-4-pyridine

Round 1

Reviewer 1 Report

This manuscript presents a new structure obtained in a simple reaction and thus, it fits the criteria for publication in Molbank. The structure is confirmed by x-ray analysis, but NMR and mass spectroscopy data are also provided.

The manuscript is easy to follow, and the English is correct.

However, some corrections are needed.

No figure 1 exists. Figure 2 should be relabeled.

The abbreviation for perfluoropyridine should be introduced in the first appearance of the term, in line 32 and not in line 37.

It is not correct to state that the HOMO orbital describes the pathway of the reaction. From the analysis of that orbital the conclusion is only that there is less electron density at the para position of the PFP and thus, the nucleophile can easily approach that position. The attack must be on the empty LUMO orbital, which is larger at that position.

Water is needed for the reaction to proceed, but in the experimental part, no water is included. The source of water must be indicated.

Author Response

Response to reviewer:

1. No figure 1 exists. Figure 2 should be relabeled. 

Corrected.

2, The abbreviation for perfluoropyridine should be introduced in the first appearance of the term, in line 32 and not in line 37.

Corrected.

3. It is not correct to state that the HOMO orbital describes the pathway of the reaction. From the analysis of that orbital the conclusion is only that there is less electron density at the para position of the PFP and thus, the nucleophile can easily approach that position. The attack must be on the empty LUMO orbital, which is larger at that position.

Corrected.

4. Water is needed for the reaction to proceed, but in the experimental part, no water is included. The source of water must be indicated.

Response to reviewer:

1. No figure 1 exists. Figure 2 should be relabeled. 

Corrected.

2, The abbreviation for perfluoropyridine should be introduced in the first appearance of the term, in line 32 and not in line 37.

Corrected.

3. It is not correct to state that the HOMO orbital describes the pathway of the reaction. From the analysis of that orbital the conclusion is only that there is less electron density at the para position of the PFP and thus, the nucleophile can easily approach that position. The attack must be on the empty LUMO orbital, which is larger at that position.

Corrected.

4. Water is needed for the reaction to proceed, but in the experimental part, no water is included. The source of water must be indicated.

Updated the amount of water in ACN the experimental section as well as correction in Scheme 2 reaction arrow.