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Molbank
Volume 2023
Issue 3
10.3390/M1696
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Short Note

28-O-Acetyl-3-O′-(prop-2-enoyl)betulin

by
Ewa Bębenek
*,
Elwira Chrobak
and
Monika Kadela-Tomanek
Department of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, 4 Jagiellońska Str., 41-200 Sosnowiec, Poland
*
Author to whom correspondence should be addressed.
Molbank 2023, 2023(3), M1696; https://doi.org/10.3390/M1696
Submission received: 31 May 2023 / Revised: 11 July 2023 / Accepted: 12 July 2023 / Published: 14 July 2023
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Abstract

28-Acetylbetulin is a good starting compound for the synthesis of 3- or 3,28-substituted betulin derivatives with biological activity. The final product of the reaction of 28-acetylbetulin and acrylic acid under Steglich esterification conditions produced a new 3-alkenyl betulin derivative. The structure of the obtained compound was confirmed based on the analysis of NMR, IR, EI MS, and HRMS spectra. Selected pharmacokinetic parameters related to the absorption and distribution were calculated for the new betulin derivative using in silico methods.
Keywords: betulin; synthesis; ADME betulin; synthesis; ADME

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MDPI and ACS Style

Bębenek, E.; Chrobak, E.; Kadela-Tomanek, M. 28-O-Acetyl-3-O′-(prop-2-enoyl)betulin. Molbank 2023, 2023, M1696. https://doi.org/10.3390/M1696

AMA Style

Bębenek E, Chrobak E, Kadela-Tomanek M. 28-O-Acetyl-3-O′-(prop-2-enoyl)betulin. Molbank. 2023; 2023(3):M1696. https://doi.org/10.3390/M1696

Chicago/Turabian Style

Bębenek, Ewa, Elwira Chrobak, and Monika Kadela-Tomanek. 2023. "28-O-Acetyl-3-O′-(prop-2-enoyl)betulin" Molbank 2023, no. 3: M1696. https://doi.org/10.3390/M1696

APA Style

Bębenek, E., Chrobak, E., & Kadela-Tomanek, M. (2023). 28-O-Acetyl-3-O′-(prop-2-enoyl)betulin. Molbank, 2023(3), M1696. https://doi.org/10.3390/M1696

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