4-(2,5-Dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine
Round 1
Reviewer 1 Report
- The name acetonylacetone is recommended to be replaced by the IUPAC name 2,5-hexanedione
- Hypothetical compound 6 should be named according to IUPAC
-The signals of the carbon atoms in the 13C NMR spectrum are recommended to be assigned exactly to the corresponding atoms in the molecule (for this purpose the two-dimensional 1H-13C HSQC and HMBC spectra are recommended)
- By achieving the two-dimensional spectra 1H-15N HSQC and HMBC it could be highlighted even more synthesis of compound 5
Author Response
Reviewer 1
The authors are grateful to the reviewer for a kind and highly professional review.
Point 1.
The name acetonylacetone is recommended to be replaced by the IUPAC name 2,5-hexanedione
Response from authors.
The name acetonylacetone is replaced by 2,5-hexanedione throughout to the text.
Point 2.
Hypothetical compound 6 should be named according to IUPAC.
Response from authors.
The name of compound 6 is given in the paper.
Point 3.
The signals of the carbon atoms in the 13C NMR spectrum are recommended to be assigned exactly to the corresponding atoms in the molecule (for this purpose the two-dimensional 1H-13C HSQC and HMBC spectra are recommended).
Response from authors.
The authors believe that in this case there is no need to obtain complex NMR spectra, since the presence of an amino group in molecule 5 is strictly proved by the data of IR and NMR spectra, and two signals in the region of 150 ppm can be confidently attributed to the signals of carbon atoms of the 1,2,5-oxadiazole cycle bound to the nitrogen atom. The remaining signal in the 13C NMR spectrum can also be confidently attributed to the signal of a quaternary carbon atom of the pyrrole cycle by its chemical shift. The corresponding signal assignments have been added to the experimental part of the paper.
Point 4.
By achieving the two-dimensional spectra 1H-15N HSQC and HMBC it could be highlighted even more synthesis of compound 5.
Response from authors.
The authors believe that in this case there is no need to obtain complex NMR spectra, since the presence of an amino group in molecule 5 is strictly proved by the data of IR and NMR spectra, and two signals in the region of 150 ppm can be confidently attributed to the signals of carbon atoms of the 1,2,5-oxadiazole cycle bound to the nitrogen atom. The remaining signal in the 13C NMR spectrum can also be confidently attributed to the signal of a quaternary carbon atom of the pyrrole cycle by its chemical shift. The corresponding signal assignments have been added to the experimental part of the paper.
