Next Article in Journal
Ethyl 2-(12-Oxo-10,12-dihydroisoindolo[1,2-b] Quinazolin-10-yl) Acetate
Next Article in Special Issue
N-[1-(2-Chlorophenyl)-2-{1-methyl-5-nitro-4-[(phenylsulfonyl)methyl]-1H-imidazol-2-yl}ethyl]-4-methylbenzenesulfonamide
Previous Article in Journal
Synthesis and Inhibition of Influenza H1N1 Virus by Propargylaminoalkyl Derivative of Lithocholic Acid
Previous Article in Special Issue
3a-(4-Chlorophenyl)-1-methyl-3a,4-dihydroimidazo[1,5-a]quinazolin-5(3H)-one: Synthesis and In Silico Evaluation as a Ligand in the µ-Opioid Receptor
 
 
Short Note
Peer-Review Record

2-(2,5-Dimethoxyphenyl)pyrrole-3-carbonitrile

Molbank 2023, 2023(2), M1627; https://doi.org/10.3390/M1627
by Yannic Grimm, Dieter Schollmeyer and Heiner Detert *
Reviewer 1:
Molbank 2023, 2023(2), M1627; https://doi.org/10.3390/M1627
Submission received: 21 March 2023 / Revised: 11 April 2023 / Accepted: 13 April 2023 / Published: 20 April 2023
(This article belongs to the Collection Heterocycle Reactions)

Round 1

Reviewer 1 Report

In this manuscript, the authors described the synthesis and characterization of 2-(2,5-Dimethoxyphenyl)pyrrole-3-carbonitrile which was produced during the Cadogan reaction of 2-(2',5'-dimethoxyphenyl)-3-nitropyridine as a side product. The procedure for the isolation and purification of the title compound is clear, and the characterization of the title compound was well supported by NMR spectrum including 1H, 13C, COSY, HSQC, and HMBC. The authors also carried out X-ray analysis to confirm the structure of the title compound. Therefore, this review supports the acceptance of the manuscript in Molbank, however, several issues should be addressed prior to the publication.

1. Although the authors mentioned mass and IR in the manuscript, there are no data in Supporting Information. These data are very helpful for readers to understand the title compound. Please add these data in the revised Supporting Information.

2. In SI, page 2, the integration of two aliphatic peaks was missed in the 1H NMR of the starting material.

3. In SI, page 3, the chemical shifts of two aliphatic carbons were not assigned in 13C NMR of the title compound.

4. minor errors

- In page 2, line 59, the 1 in "(A, B, C, D) of 1" should be bold.

- In page 3, line 96, the "," is needed between NaHCO3 and 7 mL.

- In page 4, line 111, "pyridine(71 mg, 0.27 mmol)" should be "pyridine (71 mg, 0.27 mmol)"

Author Response

Dear reviewer,

thanks for your careful reading and helpful comments.

The changed in the main text have been made, the H-NMR of dimethoxyphenylnitropyridine contains the integration of the methoxy signals, the shifts of the methoxy carbons in the C-NMR have been added, also the IR spectrum. Unfortunately, we are not able to present the MS due to corrupted data file.

sincerely,

Heiner Detert

Back to TopTop