Review Reports

Round 1

Reviewer 1 Report

In this manuscript, the authors described the synthesis and characterization of 2-(2,5-Dimethoxyphenyl)pyrrole-3-carbonitrile which was produced during the Cadogan reaction of 2-(2',5'-dimethoxyphenyl)-3-nitropyridine as a side product. The procedure for the isolation and purification of the title compound is clear, and the characterization of the title compound was well supported by NMR spectrum including 1H, 13C, COSY, HSQC, and HMBC. The authors also carried out X-ray analysis to confirm the structure of the title compound. Therefore, this review supports the acceptance of the manuscript in Molbank, however, several issues should be addressed prior to the publication.

1. Although the authors mentioned mass and IR in the manuscript, there are no data in Supporting Information. These data are very helpful for readers to understand the title compound. Please add these data in the revised Supporting Information.

2. In SI, page 2, the integration of two aliphatic peaks was missed in the 1H NMR of the starting material.

3. In SI, page 3, the chemical shifts of two aliphatic carbons were not assigned in 13C NMR of the title compound.

4. minor errors

- In page 2, line 59, the 1 in "(A, B, C, D) of 1" should be bold.

- In page 3, line 96, the "," is needed between NaHCO₃ and 7 mL.

- In page 4, line 111, "pyridine(71 mg, 0.27 mmol)" should be "pyridine (71 mg, 0.27 mmol)"

Author Response

Dear reviewer,

thanks for your careful reading and helpful comments.

The changed in the main text have been made, the H-NMR of dimethoxyphenylnitropyridine contains the integration of the methoxy signals, the shifts of the methoxy carbons in the C-NMR have been added, also the IR spectrum. Unfortunately, we are not able to present the MS due to corrupted data file.

sincerely,

Heiner Detert