N-[3-(Chloromethyl)-1,2-benzisoxazol-5-yl]acetamide
Round 1
Reviewer 1 Report
The paper is well-written and suitable for publication. One minor thing, in the SI the NMR solvent should be included in the title of the figures.
Author Response
The authors are grateful to the reviewer for a kind and highly professional review.
Point 1.
One minor thing, in the SI the NMR solvent should be included in the title of the figures.
Response from authors.
Corrected in the SI as suggested by the reviewer.
Reviewer 2 Report
Functionally substituted 1,2-benzisoxazoles are very important and promising heterocycles with various pharmacological activities. Benzoxazoles containing reactive 3-chloromethyl and 5-amino groups are practically unexplored derivatives in this series. The authors described the simple method for the synthesis of N-[3-(сhloromethyl)-1,2-benzisoxazol-5-yl]acetamide which is an interesting precursor for the preparation of a series of 3,5-disubstituted benzoxazoles. The structure of the synthesized compound was established by elemental analysis, high-resolution mass-spectrometry, 1Н, 13C NMR and IR spectroscopy, and mass spectrometry. I do believe the manuscript could be published in molbank, after minor revisions listed below:
1. Please provide mass spectroscopic results of compound 1 and discuss them in the Results and Discussion section. (Line 49 of page 2)
2. There is no carbonyl group in compound 1. What does “The IR spectrum contains signals characteristic of the acetamide group: NH (3300 cm–1) and C=O (3300 cm–1)” mean? (Page 2)
3. The solvent was distilled off in vacuo, and the residue was treated with water and hydrochloric acid to pH 4÷5. Please modify the symbol “÷”. (Line 73 of page 2)
Author Response
The authors are grateful to the reviewer for a kind and highly professional review.
Point 1.
Please provide mass spectroscopic results of compound 1 and discuss them in the Results and Discussion section. (Line 49 of page 2)
Response from authors.
Added discussion of mass spectroscopy results.
Point 2.
There is no carbonyl group in compound 1. What does “The IR spectrum contains signals characteristic of the acetamide group: NH (3300 cm–1) and C=O (3300 cm–1)” mean? (Page 2)
Response from authors.
The signal of the carbonyl group of acetamide is corrected to 1661 cm-1.
Point 3.
The solvent was distilled off in vacuo, and the residue was treated with water and hydrochloric acid to pH 4÷5. Please modify the symbol “÷”. (Line 73 of page 2)
Response from authors.
Corrected as suggested by the reviewer to “pH 4-5”.
