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Volume 2022
Issue 2
10.3390/M1372
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Communication

Synthesis and Structure Determination of 2-Cyano-3-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)acrylamide

by
Benson M. Kariuki
1,
Bakr F. Abdel-Wahab
2,
Hanan A. Mohamed
2 and
Gamal A. El-Hiti
3,*
1
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK
2
Applied Organic Chemistry Department, Chemical Industries Research Institute, National Research Centre, Dokki, Giza 12622, Egypt
3
Cornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia
*
Author to whom correspondence should be addressed.
Molbank 2022, 2022(2), M1372; https://doi.org/10.3390/M1372
Submission received: 1 May 2022 / Revised: 25 May 2022 / Accepted: 28 May 2022 / Published: 30 May 2022
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Abstract

2-Cyano-3-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)acrylamide (3) was synthesized in 90% yield from condensation of equimolar equivalents of 1-phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde (1) and 2-cyanoacetamide (2) in boiling ethanol under basic condition for 45 min. The structure of 3 was determined using NMR spectroscopy and single crystal X-ray diffraction.
Keywords: synthesis; X-ray crystal structure; heterocycles; pyrazole; thiophene synthesis; X-ray crystal structure; heterocycles; pyrazole; thiophene
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MDPI and ACS Style

Kariuki, B.M.; Abdel-Wahab, B.F.; Mohamed, H.A.; El-Hiti, G.A. Synthesis and Structure Determination of 2-Cyano-3-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)acrylamide. Molbank 2022, 2022, M1372. https://doi.org/10.3390/M1372

AMA Style

Kariuki BM, Abdel-Wahab BF, Mohamed HA, El-Hiti GA. Synthesis and Structure Determination of 2-Cyano-3-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)acrylamide. Molbank. 2022; 2022(2):M1372. https://doi.org/10.3390/M1372

Chicago/Turabian Style

Kariuki, Benson M., Bakr F. Abdel-Wahab, Hanan A. Mohamed, and Gamal A. El-Hiti. 2022. "Synthesis and Structure Determination of 2-Cyano-3-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)acrylamide" Molbank 2022, no. 2: M1372. https://doi.org/10.3390/M1372

APA Style

Kariuki, B. M., Abdel-Wahab, B. F., Mohamed, H. A., & El-Hiti, G. A. (2022). Synthesis and Structure Determination of 2-Cyano-3-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)acrylamide. Molbank, 2022(2), M1372. https://doi.org/10.3390/M1372

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