Next Article in Journal
A Concise Synthesis towards Antimalarial Quinazolinedione TCMDC-125133 and Its Anti-Proliferative Activity against MCF-7
Previous Article in Journal
Short Note

2-(5-Acetyl-7-methoxy-2-(4-methoxyphenyl)benzofuran-3-yl)acetic Acid

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Science, Leninsky Pr., 47, 119991 Moscow, Russia
Author to whom correspondence should be addressed.
Academic Editor: Nicholas E. Leadbeater
Molbank 2022, 2022(2), M1357;
Received: 17 March 2022 / Revised: 23 March 2022 / Accepted: 24 March 2022 / Published: 1 April 2022
(This article belongs to the Section Organic Synthesis)
We elaborated a convenient one-step approach for the synthesis of previously unknown 2-(5-acetyl-7-methoxy-2-(4-methoxyphenyl)benzofuran-3-yl)acetic acid. The suggested protocol includes the multicomponent reaction of acetovanillone, 4-methoxyphenylglyoxal and Meldrum’s acid. We have demonstrated that the considered reaction is a one-pot telescoped process including the preliminary condensation of the components in MeCN followed by acid-catalyzed cyclization. The structure of the synthesized product was confirmed by 1H, 13C-NMR spectroscopy and high-resolution mass-spectrometry. View Full-Text
Keywords: acetovanillone; arylglyoxal; meldrum’s acid; multicomponent reaction acetovanillone; arylglyoxal; meldrum’s acid; multicomponent reaction
Show Figures

Graphical abstract

MDPI and ACS Style

Lichitsky, B.V.; Komogortsev, A.N.; Melekhina, V.G. 2-(5-Acetyl-7-methoxy-2-(4-methoxyphenyl)benzofuran-3-yl)acetic Acid. Molbank 2022, 2022, M1357.

AMA Style

Lichitsky BV, Komogortsev AN, Melekhina VG. 2-(5-Acetyl-7-methoxy-2-(4-methoxyphenyl)benzofuran-3-yl)acetic Acid. Molbank. 2022; 2022(2):M1357.

Chicago/Turabian Style

Lichitsky, Boris V., Andrey N. Komogortsev, and Valeriya G. Melekhina. 2022. "2-(5-Acetyl-7-methoxy-2-(4-methoxyphenyl)benzofuran-3-yl)acetic Acid" Molbank 2022, no. 2: M1357.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop