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Volume 2022
Issue 1
10.3390/M1341
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Communication

Synthesis of 3-Aroyl-4-heteroarylpyrrole Derivatives by the Van Leusen Method

by
Jorge Trilleras
1,*,
Jairo Quiroga
2 and
Angelina Hormaza
3
1
Grupo de Investigación en Compuestos Heterocíclicos, Universidad del Atlántico, Puerto Colombia 08007, Colombia
2
Grupo de Investigación de Compuestos Heterocíclicos, Universidad del Valle, Cali 760032, Colombia
3
Grupo de Investigación en Síntesis, Reactividad y Transformación de Compuestos Orgánicos, Universidad Nacional de Colombia, Medellín 050022, Colombia
*
Author to whom correspondence should be addressed.
Molbank 2022, 2022(1), M1341; https://doi.org/10.3390/M1341
Submission received: 8 January 2022 / Revised: 9 February 2022 / Accepted: 9 February 2022 / Published: 15 February 2022
(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Abstract

The synthesis and structural diversification of N-heterocycles systems have attracted much attention because of their potential applications. Three 6-aryl-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde 4 derivatives, in reaction with acetophenones 5, via conventional Claisen–Schmidt condensation reactions, generated the respective enones. The enones were used as electron-deficient olefins in a “formal” [2+3] cycloaddition reaction using p-tosylmethyl isocyanide—TosMIC 7. This protocol allows access to 3-(substituted aroyl)-4-heteroaryl pyrrole derivatives by the Van Leusen method.
Keywords: 3,4-substituted pyrrole synthesis; TosMIC; Van Leusen reaction 3,4-substituted pyrrole synthesis; TosMIC; Van Leusen reaction

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MDPI and ACS Style

Trilleras, J.; Quiroga, J.; Hormaza, A. Synthesis of 3-Aroyl-4-heteroarylpyrrole Derivatives by the Van Leusen Method. Molbank 2022, 2022, M1341. https://doi.org/10.3390/M1341

AMA Style

Trilleras J, Quiroga J, Hormaza A. Synthesis of 3-Aroyl-4-heteroarylpyrrole Derivatives by the Van Leusen Method. Molbank. 2022; 2022(1):M1341. https://doi.org/10.3390/M1341

Chicago/Turabian Style

Trilleras, Jorge, Jairo Quiroga, and Angelina Hormaza. 2022. "Synthesis of 3-Aroyl-4-heteroarylpyrrole Derivatives by the Van Leusen Method" Molbank 2022, no. 1: M1341. https://doi.org/10.3390/M1341

APA Style

Trilleras, J., Quiroga, J., & Hormaza, A. (2022). Synthesis of 3-Aroyl-4-heteroarylpyrrole Derivatives by the Van Leusen Method. Molbank, 2022(1), M1341. https://doi.org/10.3390/M1341

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