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School of Health Sciences, Department of Pharmacy, Division of Pharmaceutical Chemistry, National and Kapodistrian University of Athens Panepistimioupoli-Zografou, 15784 Athens, Greece
Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research “Demokritos”, 15310 Athens, Greece
Author to whom correspondence should be addressed.
Academic Editor: Fawaz Aldabbagh
Molbank 2022, 2022(1), M1346;
Received: 2 February 2022 / Revised: 22 February 2022 / Accepted: 23 February 2022 / Published: 1 March 2022
(This article belongs to the Section Organic Synthesis)
Based on the diaryl hydroxylamine scaffold, which exhibits the potential to inhibit all three enzymes of the first step of the kynurenine pathway, the main tryptophan degradation pathway in mammals, which is often activated in cancer, we report herein the synthesis of a ferrocenyl analogue as an attempt to improve the scaffold’s pan-inhibitory potency through the isosteric replacement of a phenyl group with the ferrocenyl moiety. The synthetic methodology followed gives access to O-((ferrocenyl)(aryl)methyl)hydroxylamines, a class of compounds not yet reported in the literature. View Full-Text
Keywords: ferrocene; bioisosteric replacement; diaryl hydroxylamine; kynurenine pathway ferrocene; bioisosteric replacement; diaryl hydroxylamine; kynurenine pathway
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MDPI and ACS Style

Foscolos, A.S.; Georgiou, M.; Papadopoulos, M.S.; Chiotellis, A. O-((Ferrocenyl)(3-fluorophenyl)methyl)hydroxylamine. Molbank 2022, 2022, M1346.

AMA Style

Foscolos AS, Georgiou M, Papadopoulos MS, Chiotellis A. O-((Ferrocenyl)(3-fluorophenyl)methyl)hydroxylamine. Molbank. 2022; 2022(1):M1346.

Chicago/Turabian Style

Foscolos, Angeliki S., Maria Georgiou, Minas S. Papadopoulos, and Aristeidis Chiotellis. 2022. "O-((Ferrocenyl)(3-fluorophenyl)methyl)hydroxylamine" Molbank 2022, no. 1: M1346.

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