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Short Note

6-(Chloromethyl)-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia
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Author to whom correspondence should be addressed.
Academic Editor: Fawaz Aldabbagh
Molbank 2021, 2021(4), M1294; https://doi.org/10.3390/M1294
Received: 19 October 2021 / Revised: 26 October 2021 / Accepted: 27 October 2021 / Published: 1 November 2021
(This article belongs to the Collection Heterocycle Reactions)
Functionally 4,6-disubstituted 1H-pyrazolo[3,4-d]pyrimidines are important compounds with various pharmacological activities. 1-Substituted 4-chloro-6-(chloromethyl)-1H-pyrazolo[3,4-d]pyrimidines are practically unexplored derivatives in this series. In this paper, it was shown that the nucleophilic substitution of 4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine with methylamine produced selectively 4-substituted product, 6-(chloromethyl)-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. The structure of the synthesized compound was established by elemental analysis, high resolution mass-spectrometry, 1H, 13C-NMR, and IR spectroscopy, mass-spectrometry, and X-ray analysis. View Full-Text
Keywords: 1H-pyrazolo[3,4-d]pyrimidines; 6-(chloromethyl)-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine; nucleophilic substitution; X-ray analysis; biological activity 1H-pyrazolo[3,4-d]pyrimidines; 6-(chloromethyl)-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine; nucleophilic substitution; X-ray analysis; biological activity
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MDPI and ACS Style

Ogurtsov, V.A.; Rakitin, O.A. 6-(Chloromethyl)-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Molbank 2021, 2021, M1294. https://doi.org/10.3390/M1294

AMA Style

Ogurtsov VA, Rakitin OA. 6-(Chloromethyl)-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Molbank. 2021; 2021(4):M1294. https://doi.org/10.3390/M1294

Chicago/Turabian Style

Ogurtsov, Vladimir A., and Oleg A. Rakitin 2021. "6-(Chloromethyl)-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine" Molbank 2021, no. 4: M1294. https://doi.org/10.3390/M1294

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