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Multicomponent Approach to the Synthesis of 4-(1H-indol-3-yl)-5-(4-methoxyphenyl)furan-2(5H)-one

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Science, Leninsky Pr., 47, 119991 Moscow, Russia
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Academic Editor: Raffaella Mancuso
Molbank 2021, 2021(4), M1292; https://doi.org/10.3390/M1292
Received: 1 October 2021 / Revised: 25 October 2021 / Accepted: 27 October 2021 / Published: 29 October 2021
(This article belongs to the Section Organic Synthesis)
A simple one-pot approach was developed for the synthesis of furan-2(5H)-one derivative containing indole fragments. This method includes the telescoped multicomponent reaction of indole, 4-methoxyphenylglyoxal, and Meldrum’s acid. The synthetic utility of the prepared furan-2(5H)-one was demonstrated by condensation with 4-methoxybenzaldehyde. The advantages of this method include the employment of readily accessible starting materials, atom economy, process simplicity, and the easy isolation of the target products. The structure of the synthesized furanones was confirmed by 1H and 13C-NMR spectroscopy and high-resolution mass spectrometry with electrospray ionization (ESI-HRMS). View Full-Text
Keywords: furan-2(5H)-one; indole; arylglyoxals; Meldrum’s acid; multicomponent reaction furan-2(5H)-one; indole; arylglyoxals; Meldrum’s acid; multicomponent reaction
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MDPI and ACS Style

Komogortsev, A.N.; Lichitsky, B.V.; Melekhina, V.G. Multicomponent Approach to the Synthesis of 4-(1H-indol-3-yl)-5-(4-methoxyphenyl)furan-2(5H)-one. Molbank 2021, 2021, M1292. https://doi.org/10.3390/M1292

AMA Style

Komogortsev AN, Lichitsky BV, Melekhina VG. Multicomponent Approach to the Synthesis of 4-(1H-indol-3-yl)-5-(4-methoxyphenyl)furan-2(5H)-one. Molbank. 2021; 2021(4):M1292. https://doi.org/10.3390/M1292

Chicago/Turabian Style

Komogortsev, Andrey N., Boris V. Lichitsky, and Valeriya G. Melekhina 2021. "Multicomponent Approach to the Synthesis of 4-(1H-indol-3-yl)-5-(4-methoxyphenyl)furan-2(5H)-one" Molbank 2021, no. 4: M1292. https://doi.org/10.3390/M1292

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