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2-((4-((E)-1-(Hydroxyimino)ethyl)phenyl)amino)-2-oxoethyl Cinnamate

Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Author to whom correspondence should be addressed.
Academic Editor: Nicholas E. Leadbeater
Molbank 2021, 2021(3), M1239;
Received: 31 May 2021 / Revised: 22 June 2021 / Accepted: 23 June 2021 / Published: 25 June 2021
Cinnamic acid-nitric oxide (NO) donor hybrids have attracted attention, in recent years, as new pharmacological agents to treat multifactorial diseases. In the present study, hybrid oxime 5 was synthesized and its anti-lipid peroxidation and anti-lipoxygenase activities were evaluated. The new compound showed remarkable anti-LOX activity, while its antioxidant activity was quite good in comparison to the appropriate reference compounds. The examined derivative seems to be orally active in accordance to Lipinski’s rule of five. Compound 5 can be considered as a leading structure for the design and synthesis of new hybrids. View Full-Text
Keywords: cinnamic acid; NO donor; hybrids; LOX; antioxidant activity cinnamic acid; NO donor; hybrids; LOX; antioxidant activity
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MDPI and ACS Style

Tsopka, I.-C.; Hadjipavlou-Litina, D. 2-((4-((E)-1-(Hydroxyimino)ethyl)phenyl)amino)-2-oxoethyl Cinnamate. Molbank 2021, 2021, M1239.

AMA Style

Tsopka I-C, Hadjipavlou-Litina D. 2-((4-((E)-1-(Hydroxyimino)ethyl)phenyl)amino)-2-oxoethyl Cinnamate. Molbank. 2021; 2021(3):M1239.

Chicago/Turabian Style

Tsopka, Ioanna-Chrysoula, and Dimitra Hadjipavlou-Litina. 2021. "2-((4-((E)-1-(Hydroxyimino)ethyl)phenyl)amino)-2-oxoethyl Cinnamate" Molbank 2021, no. 3: M1239.

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