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Communication

Ammonium Salts of 5-(3-Chromenyl)-5H-chromeno[2,3-b]pyridines

N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia
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Academic Editor: Nicholas E. Leadbeater
Molbank 2021, 2021(2), M1219; https://doi.org/10.3390/M1219
Received: 29 April 2021 / Revised: 18 May 2021 / Accepted: 21 May 2021 / Published: 30 May 2021
(This article belongs to the Section Organic Synthesis)
The ammonium salts of many drugs have significantly improved the solubility and, accordingly, the bioavailability of medicinal substances in the human body. 5-(4-Hydroxy-2-oxo-2H-chromen-3-yl)-5H-chromeno[2,3-b]pyridines are potential NPY1R ligands, which are attractive for antiobesity treatment. Ammonium salts of 5H-chromeno[2,3-b]pyridines were previously unknown. In this communication, it was found that the four-component reaction of salicylaldehyde, 2-aminoprop-1-ene-1,1,3-tricarbonitrile, 4-Hydroxy-2H-chromen-2-one and amines results in the formation of ammonium salts of 5-(3-chromenyl)-5H-chromeno[2,3-b]pyridines. The structure of these previously unknown compounds was confirmed by means of 1H, 13C NMR and IR spectroscopy, mass spectrometry and elemental analysis. View Full-Text
Keywords: 5-(3-chromenyl)-5H-chromeno[2,3-b]pyridine; ammonium salts; morpholine; piperidine; triethylamine; diethylamine; salicylaldehyde; malononitrile dimer; 4-Hydroxy-2H-chromen-2-one 5-(3-chromenyl)-5H-chromeno[2,3-b]pyridine; ammonium salts; morpholine; piperidine; triethylamine; diethylamine; salicylaldehyde; malononitrile dimer; 4-Hydroxy-2H-chromen-2-one
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MDPI and ACS Style

Ryzhkova, Y.E.; Fakhrutdinov, A.N.; Elinson, M.N. Ammonium Salts of 5-(3-Chromenyl)-5H-chromeno[2,3-b]pyridines. Molbank 2021, 2021, M1219. https://doi.org/10.3390/M1219

AMA Style

Ryzhkova YE, Fakhrutdinov AN, Elinson MN. Ammonium Salts of 5-(3-Chromenyl)-5H-chromeno[2,3-b]pyridines. Molbank. 2021; 2021(2):M1219. https://doi.org/10.3390/M1219

Chicago/Turabian Style

Ryzhkova, Yuliya E.; Fakhrutdinov, Artem N.; Elinson, Michail N. 2021. "Ammonium Salts of 5-(3-Chromenyl)-5H-chromeno[2,3-b]pyridines" Molbank 2021, no. 2: M1219. https://doi.org/10.3390/M1219

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