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Molbank
Volume 2020
Issue 2
10.3390/M1125
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Short Note

Improved Synthesis and Determination of the Biologically Active Diastereomer of YK11

by
Yuichiro Kanno
,
Taichi Kusakabe
,
Nao Saito
,
Shoko Kikkawa
,
Keisuke Takahashi
,
Isao Azumaya
,
Kiyomitsu Nemoto
* and
Keisuke Kato
*
Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan
*
Authors to whom correspondence should be addressed.
Molbank 2020, 2020(2), M1125; https://doi.org/10.3390/M1125
Submission received: 8 April 2020 / Revised: 18 April 2020 / Accepted: 20 April 2020 / Published: 21 April 2020
(This article belongs to the Section Organic Synthesis and Biosynthesis)
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Abstract

The palladium catalyzed carbonylation of 1 using the chiral ligand L1 afforded 2 in a highly diastereoselective manner. The stereochemistry of the major diastereomer 2a was determined by X-ray crystallographic analysis. AR luciferase reporter assay studies suggested that 2a was the active constituent of YK11 (2).
Keywords: YK11; SARMs; palladium; carbonylation; orthoester YK11; SARMs; palladium; carbonylation; orthoester
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MDPI and ACS Style

Kanno, Y.; Kusakabe, T.; Saito, N.; Kikkawa, S.; Takahashi, K.; Azumaya, I.; Nemoto, K.; Kato, K. Improved Synthesis and Determination of the Biologically Active Diastereomer of YK11. Molbank 2020, 2020, M1125. https://doi.org/10.3390/M1125

AMA Style

Kanno Y, Kusakabe T, Saito N, Kikkawa S, Takahashi K, Azumaya I, Nemoto K, Kato K. Improved Synthesis and Determination of the Biologically Active Diastereomer of YK11. Molbank. 2020; 2020(2):M1125. https://doi.org/10.3390/M1125

Chicago/Turabian Style

Kanno, Yuichiro, Taichi Kusakabe, Nao Saito, Shoko Kikkawa, Keisuke Takahashi, Isao Azumaya, Kiyomitsu Nemoto, and Keisuke Kato. 2020. "Improved Synthesis and Determination of the Biologically Active Diastereomer of YK11" Molbank 2020, no. 2: M1125. https://doi.org/10.3390/M1125

APA Style

Kanno, Y., Kusakabe, T., Saito, N., Kikkawa, S., Takahashi, K., Azumaya, I., Nemoto, K., & Kato, K. (2020). Improved Synthesis and Determination of the Biologically Active Diastereomer of YK11. Molbank, 2020(2), M1125. https://doi.org/10.3390/M1125

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