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Doctoral Training “Bioactive Molecules, Health and Biotechnology”, Center of Doctoral Studies “Sciences and Technology’’, Faculty of Sciences Dhar Mahraz, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco
Organic Chemistry Laboratory (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, Fez 30000, Morocco
Organic Chemistry Laboratory (LCO), Faculty of Sciences, Ibn Zohr University, P.B 8106, Cité Dakhla, Agadir 80060, Morocco
Author to whom correspondence should be addressed.
Molbank 2019, 2019(3), M1074;
Received: 30 June 2019 / Revised: 12 July 2019 / Accepted: 16 July 2019 / Published: 19 July 2019
(This article belongs to the Special Issue Heterocycle Reactions)
PDF [1523 KB, uploaded 23 July 2019]


The compound, 4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-4-methyl-2-phenyl-4,5-dihydrooxazole 2 was prepared in high yield, through nucleophilic substitution reaction of the O-tosyl oxazoline derivative 1, by heating in dimethyl sulfoxide (DMSO) and in presence of KOH as base. The structure of the synthesized compound was established on the basis of NMR spectroscopy (1H, 13C), MS data and elemental analysis. View Full-Text
Keywords: oxazoline; pyrazole; N-alkylation; 2D NMR oxazoline; pyrazole; N-alkylation; 2D NMR
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Hajib, S.; Alami, A.; Faraj, H.; Aouine, Y. 4-[(3,5-Dimethyl-1H-pyrazol-1-yl)methyl]-4-methyl-2-phenyl-4,5-dihydrooxazole. Molbank 2019, 2019, M1074.

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