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Open AccessCommunication

Synthesis of Imine Congeners of Resveratrol and Evaluation of Their Anti-Platelet Activity

1
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Chemistry, Islamic Azad University-Pharmaceutical Sciences Branch (IAUPS), Tehran 11369, Iran
2
Chemistry Department, Faculty of Sciences, Shahid Rajaee Teacher Training University, Lavizan 16785-163, Tehran, Iran
3
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 14155-6153, Iran
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Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 11369, Iran
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Department of Agricultural and Environmental Sciences, Milan State University Via G. Celoria 2, 20133 Milan, Italy
6
Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615585, Iran
*
Authors to whom correspondence should be addressed.
Molbank 2019, 2019(1), M1039; https://doi.org/10.3390/M1039
Received: 27 November 2018 / Revised: 19 December 2018 / Accepted: 20 December 2018 / Published: 22 December 2018
(This article belongs to the Section Natural Products)
Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a cardioprotective phytochemical occurring in many plant products. In this study, a new series of imine congeners of resveratrol has been synthesized in which the imine moiety replaced the double bond in the structure of resveratrol. In addition, the in vitro antiplatelet activity of these resveratrol derivatives has been evaluated against adenosine diphosphate (ADP), arachidonic acid (AA), and collagen as platelet aggregation inducers. In general, the synthesized compounds were active as antiplatelet agents, and, therefore, the imine functional group may be considered as an effective replacement for a double bond in resveratrol for developing new and promising antiplatelet drugs. View Full-Text
Keywords: stilbenes; cardioprotection; antiplatelet drugs; polyphenols stilbenes; cardioprotection; antiplatelet drugs; polyphenols
MDPI and ACS Style

Bigdeli, M.; Sabbaghan, M.; Esfahanizadeh, M.; Kobarfard, F.; Vitalini, S.; Iriti, M.; Sharifi-Rad, J. Synthesis of Imine Congeners of Resveratrol and Evaluation of Their Anti-Platelet Activity. Molbank 2019, 2019, M1039.

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