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Ethyl 5-methyl-7-(4-morpholinophenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate

Department of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya 60115, Indonesia
Department of Chemistry, Tadulako University, Palu 94118, Indonesia
Author to whom correspondence should be addressed.
Molbank 2018, 2018(2), M998;
Received: 8 May 2018 / Revised: 24 May 2018 / Accepted: 24 May 2018 / Published: 28 May 2018
(This article belongs to the Special Issue Molecules from Catalytic Processes)
PDF [814 KB, uploaded 28 May 2018]


A new compound belonging to a dihydrotetrazolopyrimidine derivative, that is, ethyl 5-methyl-7-(4-morpholinophenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate, was successfully synthesized using a Biginelli reaction between 4-morpholinobenzaldehyde, ethyl acetoacetate, and 5-aminotetrazole with p-toluenesulfonic acid (pTSA) as a catalyst in ethanol under reflux. The molecular structure of the title compound was characterized on the basis of spectroscopic evidence, using FTIR, HRESI-MS, 1H- and 13C-NMR, and 2D NMR. View Full-Text
Keywords: Biginelli reaction; multicomponent reaction; dihydrotetrazolopyrimidine derivative Biginelli reaction; multicomponent reaction; dihydrotetrazolopyrimidine derivative
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Suwito, H.; Kurnyawaty, N.; Ul Haq, K.; Abdulloh, A.; Indriani, I. Ethyl 5-methyl-7-(4-morpholinophenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate. Molbank 2018, 2018, M998.

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