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Ethyl (1R*,10S*,12R*,15S*)-4-Hydroxy-2-oxo-15- (2-oxo-1-pyrrolidinyl)-9-oxatetracyclo[10.2.2.01,10.03,8]hexadeca-3,5,7,13-tetraene-13-carboxylate

1
Centro de Investigación Biomédica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad Tecnológica Equinoccial, Av. Mariscal Sucre y Mariana de Jesús, Quito 170527, Ecuador
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Instituto de Química de Recursos Naturales, Universidad de Talca, Av. Lircay s/n, Casilla 747, Talca 3460000, Chile
*
Authors to whom correspondence should be addressed.
Academic Editor: Norbert Haider
Molbank 2017, 2017(1), M928; https://doi.org/10.3390/M928
Received: 13 December 2016 / Revised: 11 January 2017 / Accepted: 13 January 2017 / Published: 18 January 2017
(This article belongs to the Section Organic Synthesis)
N-Vinylpirrolidinone reacts with (E)-ethyl 5-hydroxy-3-(4-oxo-4H-chromen-3-yl) acrylate (1) through a domino reaction similar to that reported reaction for ethyl vinyl ether. Inverse electron demand Diels–Alder (IEDDA)–elimination-IEDDA generates isomeric tetracycles 5 and 6. The assignment of the relative stereochemistry of the products was made by comparing the proton couplings with those obtained by reaction with ethyl vinyl ether. View Full-Text
Keywords: domino-reaction; inverse electron demand Diels–Alder; N-vinylpyrrolidinone; chromone derivatives domino-reaction; inverse electron demand Diels–Alder; N-vinylpyrrolidinone; chromone derivatives
MDPI and ACS Style

Heredia-Moya, J.; Araya-Maturana, R. Ethyl (1R*,10S*,12R*,15S*)-4-Hydroxy-2-oxo-15- (2-oxo-1-pyrrolidinyl)-9-oxatetracyclo[10.2.2.01,10.03,8]hexadeca-3,5,7,13-tetraene-13-carboxylate. Molbank 2017, 2017, M928.

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