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4-Chloro-6-ethoxy-2-(methylthio)pyrimidine

Department of Chemistry, University of Cyprus, P. O. Box 20537, Nicosia 1678, Cyprus
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Author to whom correspondence should be addressed.
Academic Editor: Norbert Haider
Molbank 2017, 2017(1), M923; https://doi.org/10.3390/M923
Received: 1 December 2016 / Revised: 22 December 2016 / Accepted: 26 December 2016 / Published: 29 December 2016
(This article belongs to the Section Organic Synthesis)
4,6-Dichloro-2-(methylthio)pyrimidine (3) reacts with EtONa in EtOH, at ca. 20 °C, for 2 h, to give exclusively 4-chloro-6-ethoxy-2-(methylthio)pyrimidine (5) in 89% yield. The latter is presented as a useful multifunctionalised pyrimidine scaffold. View Full-Text
Keywords: heterocycle; pyrimidine; multifunctionalised heterocycle; pyrimidine; multifunctionalised
MDPI and ACS Style

Kalogirou, A.S.; Koutentis, P.A. 4-Chloro-6-ethoxy-2-(methylthio)pyrimidine. Molbank 2017, 2017, M923.

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