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(E)-1-(2-Aminophenyl)-3-(benzo[d][1,3]dioxol-5-yl)prop-2-en-1-one

1
Department of Chemistry, Universidad del Valle, A.A. 25360 Santiago de Cali, Colombia
2
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, Scotland
*
Author to whom correspondence should be addressed.
Academic Editor: René T. Boeré
Molbank 2017, 2017(1), M924; https://doi.org/10.3390/M924
Received: 1 December 2016 / Revised: 23 December 2016 / Accepted: 28 December 2016 / Published: 30 December 2016
(This article belongs to the Section Structure Determination)
The title chalcone (E)-1-(2-aminophenyl)-3-(benzo[d][1,3]dioxol-5-yl)prop-2-en-1-one was obtained in 76% yield from a NaOH catalyzed Claisen–Schmidt condensation reaction between o-aminoacetophenone and piperonal. This product will be used as a key precursor for the development of an alternative route for the total synthesis of the alkaloid Graveoline. Single crystals of the title compound suitable for X-ray diffraction were grown via slow evaporation in ethanol at room temperature. A complete crystallographic study was performed in depth to unequivocally confirm its structure. The crystal structure of the title o-aminochalcone, C16H13NO3, shows two molecules per asymmetric unit (Z = 4) and adopts an E configuration about the C=C double bond. In the title compound, the mean plane of the non-H atoms of the central chalcone fragment C—C(O)—C—C—C is as follow: [root-mean-square (r.m.s.) deviation = 0.0210 Å for A–B and 0.0493 for C–D molecules]. In the crystal, molecules are linked by N–H...O and C–H...O, hydrogen bonds forming S(6), R22(6) and edge-fused R44(24)rings along with C(18) chains running parallel to (110). View Full-Text
Keywords: o-aminoacetophenones; benzodioxolyl moiety; Claisen–Schmidt condensation; o-aminochalcones; single crystal X-ray diffraction o-aminoacetophenones; benzodioxolyl moiety; Claisen–Schmidt condensation; o-aminochalcones; single crystal X-ray diffraction
MDPI and ACS Style

Abonia, R.; Arteaga, D.; Insuasty, D.; Quiroga, J.; Insuasty, B.; Moreno-Fuquen, R.; Kennedy, A.R. (E)-1-(2-Aminophenyl)-3-(benzo[d][1,3]dioxol-5-yl)prop-2-en-1-one. Molbank 2017, 2017, M924.

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