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1,1′-{1,4-Phenylene bis[3-(6-chloro-2-methyl-4-phenylquinolin-3-yl)-4,5-dihydro-1H-pyrazole-5,1-diyl]}dibutan-1-one
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Molbank 2015, 2015(4), M869;


Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany
Center of Pharmaceutical Engeneering (PVZ), Technische Universität Braunschweig, Franz-Liszt-Straße 35A, 38106 Braunschweig, Germany
Author to whom correspondence should be addressed.
Received: 8 September 2015 / Revised: 8 October 2015 / Accepted: 13 October 2015 / Published: 23 October 2015
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The title compound was prepared by a Friedel–Crafts acylation-oxime synthesis-decarboxylation/dehydration sequence starting from commercially available 7-iodoindole with 2-(7-iodo-1H-indol-3-yl)-2-oxoacetic acid as isolated intermediate. The structural identity of the title compound was proven by elemental analysis and spectroscopic methods (IR, NMR, EI-MS), and purity was assessed by two independent HPLC methods. View Full-Text
Keywords: decarboxylation, dehydration, indole, nitrile, oxime, protein kinase inhibitor decarboxylation, dehydration, indole, nitrile, oxime, protein kinase inhibitor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Meine, R.; Falke, H.; Kötz, J.; Schweda, S.I.; Kunick, C. 7-Iodo-1H-indole-3-carbonitrile. Molbank 2015, 2015, M869.

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