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7-Iodo-1H-indole-3-carbonitrile

1
Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany
2
Center of Pharmaceutical Engeneering (PVZ), Technische Universität Braunschweig, Franz-Liszt-Straße 35A, 38106 Braunschweig, Germany
*
Author to whom correspondence should be addressed.
Molbank 2015, 2015(4), M869; https://doi.org/10.3390/M869
Received: 8 September 2015 / Revised: 8 October 2015 / Accepted: 13 October 2015 / Published: 23 October 2015
The title compound was prepared by a Friedel–Crafts acylation-oxime synthesis-decarboxylation/dehydration sequence starting from commercially available 7-iodoindole with 2-(7-iodo-1H-indol-3-yl)-2-oxoacetic acid as isolated intermediate. The structural identity of the title compound was proven by elemental analysis and spectroscopic methods (IR, NMR, EI-MS), and purity was assessed by two independent HPLC methods. View Full-Text
Keywords: decarboxylation, dehydration, indole, nitrile, oxime, protein kinase inhibitor decarboxylation, dehydration, indole, nitrile, oxime, protein kinase inhibitor
MDPI and ACS Style

Meine, R.; Falke, H.; Kötz, J.; Schweda, S.I.; Kunick, C. 7-Iodo-1H-indole-3-carbonitrile. Molbank 2015, 2015, M869.

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