Next Article in Journal
4-Chloro-2,3,5-trifluorobenzoic Acid
Previous Article in Journal
Article Menu

Export Article

Open AccessShort Note
Molbank 2015, 2015(4), M870;


Faculty of Chemistry and Pharmacy, University of Sofia “St. Kl. Ohridski”, 1, James Bourchier Blvd., 1164 Sofia, Bulgaria
Author to whom correspondence should be addressed.
Received: 30 September 2015 / Revised: 21 October 2015 / Accepted: 27 October 2015 / Published: 29 October 2015
Full-Text   |   PDF [687 KB, uploaded 29 October 2015]   |  


We report a novel protocol for the synthesis of 3-(3,4-dihydroxyphenyl)-8-hydroxy-2H-chromen-2-one via demethylation/delactonization/elimination/lactonization/ decarboxylation domino reaction sequence of diastereomeric mixture of cis- and trans-3-(2,3-dimethoxyphenyl)-6,7-dimethoxy-1-oxoisochroman-4-carboxylic acids in boiling HBr/AcOH. The structure of the target compound was established for the first time by means of spectral methods such as 1H-, 13C-, DEPT-135-NMR, IR and HRMS. View Full-Text
Keywords: polyhydroxylated 3-arylcoumarins; 3,4-dihydroisocoumarin; domino reaction polyhydroxylated 3-arylcoumarins; 3,4-dihydroisocoumarin; domino reaction

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary materials


Share & Cite This Article

MDPI and ACS Style

Svinyarov, I.; Bogdanov, M. 3-(3,4-Dihydroxyphenyl)-8-hydroxy-2H-chromen-2-one. Molbank 2015, 2015, M870.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molbank EISSN 1422-8599 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top