3-(3,4-Dihydroxyphenyl)-8-hydroxy-2H-chromen-2-one
by
Ivan Svinyarov and Milen Bogdanov *
Ivan Svinyarov and Milen Bogdanov *
Faculty of Chemistry and Pharmacy, University of Sofia “St. Kl. Ohridski”, 1, James Bourchier Blvd., 1164 Sofia, Bulgaria
*
Author to whom correspondence should be addressed.
Molbank 2015, 2015(4), M870; https://doi.org/10.3390/M870
Received: 30 September 2015 / Revised: 21 October 2015 / Accepted: 27 October 2015 / Published: 29 October 2015
We report a novel protocol for the synthesis of 3-(3,4-dihydroxyphenyl)-8-hydroxy-2H-chromen-2-one via demethylation/delactonization/elimination/lactonization/ decarboxylation domino reaction sequence of diastereomeric mixture of cis- and trans-3-(2,3-dimethoxyphenyl)-6,7-dimethoxy-1-oxoisochroman-4-carboxylic acids in boiling HBr/AcOH. The structure of the target compound was established for the first time by means of spectral methods such as 1H-, 13C-, DEPT-135-NMR, IR and HRMS.
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MDPI and ACS Style
Svinyarov, I.; Bogdanov, M. 3-(3,4-Dihydroxyphenyl)-8-hydroxy-2H-chromen-2-one. Molbank 2015, 2015, M870.
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- Supplementary File 1:
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3D structure generated by CORINA by Molecular Networks. - Supplementary File 2:
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