Next Article in Journal
Effects of Acetazolamide Combined with or without NaHCO3 on Suppressing Neoplasm Growth, Metastasis and Aquaporin-1 (AQP1) Protein Expression
Previous Article in Journal
Expression of VDAC Regulated by Extracts of Limonium sinense Ktze root Against CCl4-induced Liver Damage
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2007, 8(3), 214-228;

Antiproliferative Activity of β-Hydroxy-β-Arylalkanoic Acids

Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia
Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia
Department of Chemistry, Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, 11000 Belgrade, Serbia
Faculty of Chemistry, University of Belgrade, P.O. Box 158, 11001 Belgrade, Serbia
Author to whom correspondence should be addressed.
Received: 13 February 2007 / Accepted: 5 March 2007 / Published: 13 March 2007
(This article belongs to the Section Physical Chemistry, Theoretical and Computational Chemistry)
Full-Text   |   PDF [4170 KB, uploaded 19 June 2014]


Article describes the synthesis of fifteen β-hydroxy-β-arylalkanoic acids byReformatsky reaction using the 1-ethoxyethyl-2-bromoalkanoates, aromatic or cycloalkylketones or aromatic aldehydes. The short survey of previously reported synthetic proceduresfor title compounds, is given. The majority of obtained compounds exert antiproliferativeactivity in vitro toward human: HeLa, Fem-X cells, K562, and LS174 cells, having IC50values from 62.20 to 205 μM. The most active compound is 3-OH-2,2-di-Me-3-(4-biphenylyl)-butanoic acid, having the IC50 value 62.20 μM toward HeLa cells. Sevenexamined compounds did not affect proliferation of healthy human blood peripheralmononuclear cells (PBMC and PBMC PHA), IC50 > 300 μM. The preliminary QSARresults show that estimated lipophilicity of compounds influences their antiproliferativeactivity in the first place. The ability of dehydration, and the spatial arrangement ofhydrophobic portion, HBD and HBA in molecules are has almost equal importance aslipophilicity. View Full-Text
Keywords: β-hydroxy-β-arylalkanoic acids; Reformatsky reaction; antiproliferative activity; human dedifferentiate cells; QSAR β-hydroxy-β-arylalkanoic acids; Reformatsky reaction; antiproliferative activity; human dedifferentiate cells; QSAR
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Dilber, S.P.; Žižak, Ž.S.; Stanojković, T.P.; Juranić, Z.D.; Drakulić, B.J.; Juranić, I.O. Antiproliferative Activity of β-Hydroxy-β-Arylalkanoic Acids. Int. J. Mol. Sci. 2007, 8, 214-228.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top