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Article

Microwave-Assisted Synthesis of Phenothiazine and Qinoline Derivatives

1
“Babeș-Bolyai” University, Faculty of Chemistry and Chemical Engineering, Organic Chemistry Department, Cluj-Napoca, Romania
2
INCDTIM-Cluj-Napoca, Romania
3
Institute of Organic Chemistry, National NMR Laboratory, Bucharest, Romania
4
Universitée de la Mediteranée, Faculté de Pharmacie, Marseille, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2007, 8(2), 70-80; https://doi.org/10.3390/i8020070
Received: 27 October 2006 / Accepted: 12 February 2007 / Published: 13 February 2007
(This article belongs to the Section Physical Chemistry, Theoretical and Computational Chemistry)
Application of a dynamic microwave power system in the chemical synthesis ofsome phenothiazine and quinoline derivatives is described. Heterocyclic ring formation,aromatic nucleophilic substitution and heterocyclic aldehydes/ketones condensationreactions were performed on solid support, or under solvent free reaction conditions. Themicrowave-assisted Duff formylation of phenothiazine was achieved. Comparison ofmicrowave-assisted synthesis with the conventional synthetic methods demonstratesadvantages related to shorter reaction times and in some cases better reaction yields. View Full-Text
Keywords: MAOS; Quinoline; Pyrido[3,2-g]quinoline; Phenothiazine; formylation MAOS; Quinoline; Pyrido[3,2-g]quinoline; Phenothiazine; formylation
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MDPI and ACS Style

Găină, L.; Cristea, C.; Moldovan, C.; Porumb, D.; Surducan, E.; Deleanu, C.; Mahamoud, A.; Barbe, J.; Silberg, I.A. Microwave-Assisted Synthesis of Phenothiazine and Qinoline Derivatives. Int. J. Mol. Sci. 2007, 8, 70-80. https://doi.org/10.3390/i8020070

AMA Style

Găină L, Cristea C, Moldovan C, Porumb D, Surducan E, Deleanu C, Mahamoud A, Barbe J, Silberg IA. Microwave-Assisted Synthesis of Phenothiazine and Qinoline Derivatives. International Journal of Molecular Sciences. 2007; 8(2):70-80. https://doi.org/10.3390/i8020070

Chicago/Turabian Style

Găină, Luiza, Castelia Cristea, Claudia Moldovan, Dan Porumb, Emanoil Surducan, Calin Deleanu, Abdalah Mahamoud, Jacques Barbe, and Ioan A. Silberg 2007. "Microwave-Assisted Synthesis of Phenothiazine and Qinoline Derivatives" International Journal of Molecular Sciences 8, no. 2: 70-80. https://doi.org/10.3390/i8020070

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