Next Article in Journal
Microwave-Assisted Synthesis of Phenothiazine and Qinoline Derivatives
Next Article in Special Issue
Efficient Gene Transfection into Mammalian Cells Mediated by Cross-linked Polyethylenimine
Previous Article in Journal / Special Issue
Hsp90 Maintains the Stability and Function of the Tau Phosphorylating Kinase GSK3β
Article

Interactions between Endostatin and Vascular Endothelial Growth Factor (VEGF) and Inhibition of Choroidal Neovascularization

1
Shanghai Jiaotong University Affiliated First People’s Hospital, Shanghai 200080, China
2
Second Xiangya Hospital of Central South University, Changsha 410011, China
3
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2007, 8(1), 61-69; https://doi.org/10.3390/i8010061
Received: 3 January 2007 / Accepted: 16 January 2007 / Published: 31 January 2007
(This article belongs to the Special Issue Interaction of Biological Molecules)
This study was designed to evaluate the inhibitory effect of endostatin onchoroidal neovascularization (CNV) in laser-induced rat model. Choroidalneovascularization was induced in Brown Norway (BN) rats by diode-laserphotocoagulation. Rats were randomly divided into five groups (10 animals in each group):endostatin 20mg/kg group, endostatin 10mg/kg group, laser injury group, normal salinegroup and blank control group. The animals were treated with endostatin, normal saline,laser injury or without treatment on day 0 to day 13 after laser photocoagulation. On day 7and 14 after laser photocoagulation, the CNV formation was assessed by fluoresceinangiography and histopathological analysis. VEGF expression in retina was determined byimmunohistochemical assay. In two endostatin groups, the incidence of CNV formation andthe intensity of fluorescein leakage were reduced compared with the two control groups. Nosignificant difference was found between laser injury group and normal saline group. Theexpression of VEGF reached peak at day 7 and then decreased from day 14 afterphotocoagulation. The expression of VEGF was significantly reduced in the two endostaingroups than laser injury group in a dose-dependent way. Endostatin can inhibit the formationof experimental CNV in the rat. Down-regulation of VEGF expression could be one of themechanisms underlying the inhibition of CNV by endostatin. View Full-Text
Keywords: horoidal neovascularization; Animal model; Laser; Endostatin; VEGF horoidal neovascularization; Animal model; Laser; Endostatin; VEGF
Show Figures

MDPI and ACS Style

Wang, X.; Xu, X.; Tang, L.; Song, S.; Fan, C. Interactions between Endostatin and Vascular Endothelial Growth Factor (VEGF) and Inhibition of Choroidal Neovascularization. Int. J. Mol. Sci. 2007, 8, 61-69. https://doi.org/10.3390/i8010061

AMA Style

Wang X, Xu X, Tang L, Song S, Fan C. Interactions between Endostatin and Vascular Endothelial Growth Factor (VEGF) and Inhibition of Choroidal Neovascularization. International Journal of Molecular Sciences. 2007; 8(1):61-69. https://doi.org/10.3390/i8010061

Chicago/Turabian Style

Wang, Xun, Xun Xu, Luosheng Tang, Shiping Song, and Chunhai Fan. 2007. "Interactions between Endostatin and Vascular Endothelial Growth Factor (VEGF) and Inhibition of Choroidal Neovascularization" International Journal of Molecular Sciences 8, no. 1: 61-69. https://doi.org/10.3390/i8010061

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop