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Retraction of Int. J. Mol. Sci. 2015, 16(2), 2294-2306.
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Retraction

RETRACTED: Li et al. FBXW7 Acts as an Independent Prognostic Marker and Inhibits Tumor Growth in Human Osteosarcoma. Int. J. Mol. Sci. 2015, 16, 2294–2306

by
Zhanchun Li
1,
Jie Xiao
2,
Kongzu Hu
3,
Gang Wang
4,
Maoqiang Li
5,
Jidong Zhang
1,* and
Guangqi Cheng
1
1
Department of Orthopaedic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
2
Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
3
Department of Orthopaedic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
4
Department of Orthopaedic Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
5
Department of Orthopaedic Surgery, Hangzhou First People’s Hospital, Hangzhou 310006, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2026, 27(9), 3781; https://doi.org/10.3390/ijms27093781
Submission received: 27 February 2026 / Accepted: 30 March 2026 / Published: 24 April 2026
(This article belongs to the Section Molecular Oncology)
Versions Notes
The journal retracts the article “FBXW7 Acts as an Independent Prognostic Marker and Inhibits Tumor Growth in Human Osteosarcoma” [1], cited above.
Following publication, concerns were brought to the attention of the Editorial Office regarding a number of irregularities found in images presented in this article [1].
Adhering to our standard procedure, an investigation was conducted by the Editorial Office and Editorial Board, which confirmed indications of inappropriate image editing regarding an overlap between Figures 3D and 5 published in [1] and Figures 1A and 6B published in [2]; between Figure 3D in [1] and Figure 2D presented in [3] and Figure 4C [4]; between Figures 4B,C and 5 published in [1] and Figures 4B and 5B published in [5]; and between Figure 4A in [1] and Figure 4A published in [6], all showing different experimental conditions. As a result, the Editorial Board has lost confidence in the reliability of the findings and decided to retract this publication [1], as per MDPI’s retraction policy (https://www.mdpi.com/ethics#_bookmark30, accessed on 29 March 2026).
This retraction was approved by the Editor-in-Chief of IJMS.
The authors did not provide a comment on this decision.

References

  1. Li, Z.; Xiao, J.; Hu, K.; Wang, G.; Li, M.; Zhang, J.; Cheng, G. RETRACTED: FBXW7 Acts as an Independent Prognostic Marker and Inhibits Tumor Growth in Human Osteosarcoma. Int. J. Mol. Sci. 2015, 16, 2294–2306. [Google Scholar] [CrossRef] [PubMed]
  2. Tu, K.; Yang, W.; Li, C.; Zheng, X.; Lu, Z.; Guo, C.; Yao, Y.; Liu, Q. Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma. Mol. Cancer 2014, 13, 110. [Google Scholar] [CrossRef] [PubMed]
  3. Zheng, X.; Gai, X.; Ding, F.; Lu, Z.; Tu, K.; Yao, Y.; Liu, Q. Histone acetyltransferase PCAF up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling. Mol. Cancer 2013, 12, 96, Correction in Mol. Cancer 2022, 21, 187. https://doi.org/10.1186/s12943-022-01637-2. [Google Scholar] [CrossRef] [PubMed]
  4. Tu, K.; Zheng, X.; Zhou, Z.; Li, C.; Zhang, J.; Gao, J.; Yao, Y.; Liu, Q. Recombinant human adenovirus-p53 injection induced apoptosis in hepatocellular carcinoma cell lines mediated by p53-Fbxw7 pathway, which controls c-Myc and cyclin E. PLoS ONE 2013, 8, e68574, Retraction in PLoS ONE 2020, 15, e0231287. https://doi.org/10.1371/journal.pone.0231287. [Google Scholar] [CrossRef] [PubMed]
  5. Tu, K.; Li, C.; Zheng, X.; Yang, W.; Yao, Y.; Liu, Q. Prognostic significance of miR-218 in human hepatocellular carcinoma and its role in cell growth. Oncol. Rep. 2014, 32, 1571–1577. [Google Scholar] [CrossRef] [PubMed]
  6. Huang, Y.; Guo, W.; Kan, H. TPX2 is a prognostic marker and contributes to growth and metastasis of human hepatocellular carcinoma. Int. J. Mol. Sci. 2014, 15, 18148–18161. [Google Scholar] [CrossRef] [PubMed]
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Share and Cite

MDPI and ACS Style

Li, Z.; Xiao, J.; Hu, K.; Wang, G.; Li, M.; Zhang, J.; Cheng, G. RETRACTED: Li et al. FBXW7 Acts as an Independent Prognostic Marker and Inhibits Tumor Growth in Human Osteosarcoma. Int. J. Mol. Sci. 2015, 16, 2294–2306. Int. J. Mol. Sci. 2026, 27, 3781. https://doi.org/10.3390/ijms27093781

AMA Style

Li Z, Xiao J, Hu K, Wang G, Li M, Zhang J, Cheng G. RETRACTED: Li et al. FBXW7 Acts as an Independent Prognostic Marker and Inhibits Tumor Growth in Human Osteosarcoma. Int. J. Mol. Sci. 2015, 16, 2294–2306. International Journal of Molecular Sciences. 2026; 27(9):3781. https://doi.org/10.3390/ijms27093781

Chicago/Turabian Style

Li, Zhanchun, Jie Xiao, Kongzu Hu, Gang Wang, Maoqiang Li, Jidong Zhang, and Guangqi Cheng. 2026. "RETRACTED: Li et al. FBXW7 Acts as an Independent Prognostic Marker and Inhibits Tumor Growth in Human Osteosarcoma. Int. J. Mol. Sci. 2015, 16, 2294–2306" International Journal of Molecular Sciences 27, no. 9: 3781. https://doi.org/10.3390/ijms27093781

APA Style

Li, Z., Xiao, J., Hu, K., Wang, G., Li, M., Zhang, J., & Cheng, G. (2026). RETRACTED: Li et al. FBXW7 Acts as an Independent Prognostic Marker and Inhibits Tumor Growth in Human Osteosarcoma. Int. J. Mol. Sci. 2015, 16, 2294–2306. International Journal of Molecular Sciences, 27(9), 3781. https://doi.org/10.3390/ijms27093781

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