Correction: Vyas et al. Efficacy of Adeno-Associated Virus Serotype 9-Mediated Gene Therapy for AB-Variant GM2 Gangliosidosis. Int. J. Mol. Sci. 2023, 24, 14611

In the original publication [1], there was a mistake in the legend for Figure 5. The mistake was the labelling of D and H separately in Figure 5. The slides are from the same pool of mice at 60 weeks of age, as they are better controls for any possible GM2 accumulation to be shown. The correct legend appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

Figure 5. Sections of the murine hypothalamus, thalamus, and amygdala were stained with an anti-GM2 antibody at 15× magnification. The brown spots on the images depict GM2 accumulation. A–C depicts the short-term, 20-week cohort: (A) GFP-injected Gm2a^−/− mice; (B) ssAAV9-GM2A neonatally-injected Gm2a^−/− mice; (C) ssAAV9-GM2A adult-injected Gm2a^−/− mice; and (D,H) images from the same pool from disease-free heterozygous mice (Gm2a^+/−) at 60 weeks. E–G depicts the long-term, 60-week cohort: (E) GFP-injected Gm2a^−/− mice (n = 1), (F) ssAAV9-GM2A neonatally-injected Gm2a^−/− mice, (G) ssAAV9-GM2A adult-injected Gm2a^−/− mice. (I) In all sections of the brain at 20 weeks, Gm2a^−/− mice treated with ssAAV9-GM2A have less accumulation than GFP-injected Gm2a^−/− mice. Neonatally injected Gm2a^−/− mice have much more accumulation in the hypothalamus than adult-treated Gm2a^−/− mice. However, in the thalamus and amygdala, the adult-injected Gm2a^−/− mice have notably more accumulation than the neonatally-injected Gm2a^−/− mice. (J) In the thalamus and amygdala, ssAAV9-GM2A-treated mice have reduced accumulation compared to GFP-injected Gm2a^−/− mice. However, in the hypothalamus, ssAAV9-GM2A adult-injected Gm2a^−/− mice have substantially more GM2 than both neonatally-treated Gm2a^−/− mice and GFP-injected Gm2a^−/− mice. The black arrow indicates examples of areas saturated with GM2 accumulation.