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Review

New Strategies for the Prevention and Therapy of Alzheimer’s Disease Based on Stimulation of Brain Drainage and Lymphatic Clearance

by
Oxana Semyachkina-Glushkovskaya
1,*,
Vladislav Sursaev
2,
Mikhail Poluektov
2,
Sergey Diduk
3,4,
Liubov Rychkova
5,
Irina Madaeva
5,
Liudmila Yakubova
6 and
Jürgen Kurths
7,8,*
1
Department of Biology, Saratov State University, Astrakhanskaya 83 Str., 410012 Saratov, Russia
2
Department of Nervous Diseases and Neurosurgery, First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya 2, Building 4, 119435 Moscow, Russia
3
Department of Biotechnology, Leeners LLC, 117186 Moscow, Russia
4
Research Institute of Carcinogenesis of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, Kashirskoe Shosse 24, 115522 Moscow, Russia
5
Federal State Budgetary Scientific Institution Scientific Centre for Family Health and Human Reproduction Problems, 664003 Irkutsk, Russia
6
Department of General Medical Practice and Polyclinic Therapy, Grodno State Medical University, 230009 Grodno, Belarus
7
Research Institute of Intelligent Complex Systems, Fudan University, 220 Handan Rd, Yangpu District, Shanghai 200437, China
8
Potsdam Institute for Climate Impact Research, Telegrafenberg A 31, 14473 Potsdam, Germany
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2026, 27(5), 2312; https://doi.org/10.3390/ijms27052312
Submission received: 20 January 2026 / Revised: 24 February 2026 / Accepted: 25 February 2026 / Published: 28 February 2026
(This article belongs to the Special Issue Challenges and Innovation in Neurodegenerative Diseases, 2nd Edition)
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Abstract

Alzheimer’s disease (AD) is a serious medical challenge, representing an incurable and insidious disease. Current treatments can slow AD progression but cannot cure it. Promising new methods for AD therapy are essential for addressing the growing number of people with dementia, especially after the COVID-19 pandemic. The review highlights pioneering approaches to AD treatment based on innovative methods for the stimulation of brain drainage and clearance, in which the meningeal lymphatic vessels (MLVs) play a key role. Clinically promising noninvasive technologies using photobiomodulation for the effective clearance of metabolites, including amyloid beta (Aβ), and for the improvement of cognitive impairment during AD progression are discussed. An interesting part of the review is its analysis of innovative methods of improving the efficacy of anti-Aβ immunotherapy by stimulating MLV growth. The review is also focused on lifestyle, including sleep and physical exercises, discussing their support for the efficient lymphatic removal of waste products from the brain. Overall, the review provides an important, informative platform to excite the interest of a wide range of readers in the development of promising and clinically significant strategies for the treatment of AD, based on new strategies for the stimulation of brain drainage and clearance.
Keywords: dementia; Alzheimer’s disease; meningeal lymphatic vessels; brain drainage and clearance; photobiomodulation; pharmacological methods; sleep; physical exercise dementia; Alzheimer’s disease; meningeal lymphatic vessels; brain drainage and clearance; photobiomodulation; pharmacological methods; sleep; physical exercise

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MDPI and ACS Style

Semyachkina-Glushkovskaya, O.; Sursaev, V.; Poluektov, M.; Diduk, S.; Rychkova, L.; Madaeva, I.; Yakubova, L.; Kurths, J. New Strategies for the Prevention and Therapy of Alzheimer’s Disease Based on Stimulation of Brain Drainage and Lymphatic Clearance. Int. J. Mol. Sci. 2026, 27, 2312. https://doi.org/10.3390/ijms27052312

AMA Style

Semyachkina-Glushkovskaya O, Sursaev V, Poluektov M, Diduk S, Rychkova L, Madaeva I, Yakubova L, Kurths J. New Strategies for the Prevention and Therapy of Alzheimer’s Disease Based on Stimulation of Brain Drainage and Lymphatic Clearance. International Journal of Molecular Sciences. 2026; 27(5):2312. https://doi.org/10.3390/ijms27052312

Chicago/Turabian Style

Semyachkina-Glushkovskaya, Oxana, Vladislav Sursaev, Mikhail Poluektov, Sergey Diduk, Liubov Rychkova, Irina Madaeva, Liudmila Yakubova, and Jürgen Kurths. 2026. "New Strategies for the Prevention and Therapy of Alzheimer’s Disease Based on Stimulation of Brain Drainage and Lymphatic Clearance" International Journal of Molecular Sciences 27, no. 5: 2312. https://doi.org/10.3390/ijms27052312

APA Style

Semyachkina-Glushkovskaya, O., Sursaev, V., Poluektov, M., Diduk, S., Rychkova, L., Madaeva, I., Yakubova, L., & Kurths, J. (2026). New Strategies for the Prevention and Therapy of Alzheimer’s Disease Based on Stimulation of Brain Drainage and Lymphatic Clearance. International Journal of Molecular Sciences, 27(5), 2312. https://doi.org/10.3390/ijms27052312

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