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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Ultrastructural and Immunohistochemical Alterations in Muscle and Vascular Tissues in Patients with Omphalocele

by
Dina Rosca-Al Namat
1,†,
Adrian Romulus Rosca
1,†,
Delia Hînganu
1,*,
Ludmila Lozneanu
1,
Fabian Cezar Lupu
2,
Elena Hanganu
1,
Elena Tarca
1,
Jana Bernic
3,
Nadia Al Namat
4,
Razan Al Namat
5 and
Marius Valeriu Hînganu
1
1
Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, University Street No. 16, 700115 Iași, Romania
2
Department of Mechanical, Mechatronics and Robotics Engineering, Mechanical Engineering Faculty, Gheorghe Asachi Technical University of Iasi, 700050 Iasi, Romania
3
Discipline of Pediatric Surgery, “Nicolae Testemitanu” State University of Medicine and Pharmacy, MD-2004 Chisinau, Moldova
4
Faculty of Medicine, Dunarea de Jos University of Galati, 800008 Galati, Romania
5
Faculty of Dental Medicine, Apollonia University, 700511 Iasi, Romania
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2026, 27(3), 1460; https://doi.org/10.3390/ijms27031460 (registering DOI)
Submission received: 27 December 2025 / Revised: 28 January 2026 / Accepted: 30 January 2026 / Published: 1 February 2026
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Versions Notes

Abstract

Omphalocele is a congenital abdominal wall defect whose underlying muscular and fascial structural characteristics remain incompletely understood. This study aimed to investigate the anatomical and ultrastructural features of the abdominal wall in patients with omphalocele to provide additional insight into tissue organization at the defect margins. We report a series of 11 term-born patients diagnosed with omphalocele between 2024 and 2025 who were admitted to a pediatric surgery department for operative management. Following informed consent from legal guardians, two small intraoperative biopsies were obtained during surgical repair from the rectus abdominis muscle and its anterior aponeurosis, sampled from the supraumbilical and subumbilical regions. Tissue specimens were fixed within 48 h and analyzed using conventional histopathology and scanning electron microscopy to assess potential structural and ultrastructural alterations. The combined microscopic approaches allowed for a detailed evaluation of muscle and aponeurotic architecture in different abdominal regions. These observations contribute to a more comprehensive understanding of abdominal wall tissue characteristics in omphalocele and may support improved interpretation of the structural changes associated with this congenital condition.
Keywords: omphalocele; omphalocele molecular mechanism; scanning electron microscopy; congenital abnormalities; developmental myology omphalocele; omphalocele molecular mechanism; scanning electron microscopy; congenital abnormalities; developmental myology

Share and Cite

MDPI and ACS Style

Namat, D.R.-A.; Rosca, A.R.; Hînganu, D.; Lozneanu, L.; Lupu, F.C.; Hanganu, E.; Tarca, E.; Bernic, J.; Namat, N.A.; Al Namat, R.; et al. Ultrastructural and Immunohistochemical Alterations in Muscle and Vascular Tissues in Patients with Omphalocele. Int. J. Mol. Sci. 2026, 27, 1460. https://doi.org/10.3390/ijms27031460

AMA Style

Namat DR-A, Rosca AR, Hînganu D, Lozneanu L, Lupu FC, Hanganu E, Tarca E, Bernic J, Namat NA, Al Namat R, et al. Ultrastructural and Immunohistochemical Alterations in Muscle and Vascular Tissues in Patients with Omphalocele. International Journal of Molecular Sciences. 2026; 27(3):1460. https://doi.org/10.3390/ijms27031460

Chicago/Turabian Style

Namat, Dina Rosca-Al, Adrian Romulus Rosca, Delia Hînganu, Ludmila Lozneanu, Fabian Cezar Lupu, Elena Hanganu, Elena Tarca, Jana Bernic, Nadia Al Namat, Razan Al Namat, and et al. 2026. "Ultrastructural and Immunohistochemical Alterations in Muscle and Vascular Tissues in Patients with Omphalocele" International Journal of Molecular Sciences 27, no. 3: 1460. https://doi.org/10.3390/ijms27031460

APA Style

Namat, D. R.-A., Rosca, A. R., Hînganu, D., Lozneanu, L., Lupu, F. C., Hanganu, E., Tarca, E., Bernic, J., Namat, N. A., Al Namat, R., & Hînganu, M. V. (2026). Ultrastructural and Immunohistochemical Alterations in Muscle and Vascular Tissues in Patients with Omphalocele. International Journal of Molecular Sciences, 27(3), 1460. https://doi.org/10.3390/ijms27031460

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