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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

The Role of Natural Compounds in Bladder Urothelial Carcinoma Treatment

by
Hangfei Jiang
1,2,3,4,5,†,
Yueyin Chen
5,†,
Xi Zeng
5,
Rui Yang
5,
Feng Zhang
1,2,3,4,5,
Huanling Zhang
5,
Erxiang Zhang
5,
Xuzhang Wu
5,
Deye Yan
5 and
Chunping Yu
1,2,3,4,5,*
1
Department of Urology, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510230, China
2
Guangdong Provincial Key Laboratory of Urological Diseases, Guangzhou Medical University, Guangzhou 510230, China
3
Guangdong Engineering Research Center of Urinary Minimally Invasive Surgery Robot and Intelligent Equipment, Guangzhou Medical University, Guangzhou 510230, China
4
Guangzhou Institute of Urology, Guangzhou Medical University, Guangzhou 510230, China
5
The Third Clinical College, Guangzhou Medical University, Guangzhou 510230, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2026, 27(2), 596; https://doi.org/10.3390/ijms27020596
Submission received: 13 November 2025 / Revised: 24 December 2025 / Accepted: 29 December 2025 / Published: 7 January 2026
(This article belongs to the Section Bioactives and Nutraceuticals)
Review Reports Versions Notes

Abstract

Bladder urothelial carcinoma (BUC) ranks among the most common malignant tumors of the urinary system, with alarmingly high incidence and mortality rates. Current clinical treatments face challenges such as strong chemotherapy resistance and limited response rates to immunotherapy, creating an urgent need for novel alternative therapies. Natural products, characterized by multi-targeted antitumor activity, low toxicity, and broad availability, have emerged as highly promising adjunctive or alternative strategies in cancer treatment. Extensive research has elucidated the antitumor activities of natural products, including inhibition of cancer cell proliferation, induction of apoptosis, and modulation of the immune microenvironment. What’s more, their bioactive components, such as terpenoids and polyphenols, can synergistically enhance therapeutic efficacy while reducing toxicity risks associated with traditional therapies. This review will examine the roles of terpenoids, phenolics, alkaloids, and other natural products in BUC treatment, to provide directions for future research.
Keywords: bladder urothelial carcinoma; natural products; apoptosis; cell cycle; invasion; drug resistance bladder urothelial carcinoma; natural products; apoptosis; cell cycle; invasion; drug resistance

Share and Cite

MDPI and ACS Style

Jiang, H.; Chen, Y.; Zeng, X.; Yang, R.; Zhang, F.; Zhang, H.; Zhang, E.; Wu, X.; Yan, D.; Yu, C. The Role of Natural Compounds in Bladder Urothelial Carcinoma Treatment. Int. J. Mol. Sci. 2026, 27, 596. https://doi.org/10.3390/ijms27020596

AMA Style

Jiang H, Chen Y, Zeng X, Yang R, Zhang F, Zhang H, Zhang E, Wu X, Yan D, Yu C. The Role of Natural Compounds in Bladder Urothelial Carcinoma Treatment. International Journal of Molecular Sciences. 2026; 27(2):596. https://doi.org/10.3390/ijms27020596

Chicago/Turabian Style

Jiang, Hangfei, Yueyin Chen, Xi Zeng, Rui Yang, Feng Zhang, Huanling Zhang, Erxiang Zhang, Xuzhang Wu, Deye Yan, and Chunping Yu. 2026. "The Role of Natural Compounds in Bladder Urothelial Carcinoma Treatment" International Journal of Molecular Sciences 27, no. 2: 596. https://doi.org/10.3390/ijms27020596

APA Style

Jiang, H., Chen, Y., Zeng, X., Yang, R., Zhang, F., Zhang, H., Zhang, E., Wu, X., Yan, D., & Yu, C. (2026). The Role of Natural Compounds in Bladder Urothelial Carcinoma Treatment. International Journal of Molecular Sciences, 27(2), 596. https://doi.org/10.3390/ijms27020596

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