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Review

Elymus repens (L.) Gould Phytochemistry Pharmacological Activities and Therapeutic Potential with Future Perspectives

by
Zhakipbekov Kairat Saparkhanovich
1,
Serikbayeva Elmira Asilbekovna
1,
Tleubayeva Meruyert Ilyasovna
1,
Anarbayeva Rabiga Mutalievna
2,
Shimirova Zhanar Kasymbekovna
2,
Umurzakhova Galiya Zhanburbaevna
2,
Seitova Zhanerke Dauletkyzy
1,
Mukanova Arailym Beybitkyzy
1,
Konash Nyshanbay Yermekuly
1,*,
Ashirov Murat Zulpidinovich
1,* and
Zulpidin Gulsezim Mukhankyzy
1
1
School of Pharmacy, Asfendiyarov Kazakh National Medical University, 94, Tole Bi Str., 050012 Almaty, Kazakhstan
2
Faculty of Pharmacy, South Kazakhstan Medical Academy, Al-Farabi Square, 1, 160019 Shymkent, Kazakhstan
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2026, 27(11), 4928; https://doi.org/10.3390/ijms27114928
Submission received: 7 April 2026 / Revised: 11 May 2026 / Accepted: 20 May 2026 / Published: 29 May 2026
(This article belongs to the Special Issue The Role of Medicinal Plants in Health and Diseases)
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Abstract

Elymus repens (L.) Gould, commonly known as couch grass, is mainly distributed as a medicinal herb of great ethnopharmacological importance. This review presented for the first time the significance of nomenclature clarity, current insights on distribution, traditional use, phytochemistry and their biological activities. The bioactive compound composition of E. repens displayed a variety of compounds including carbohydrates, phenolic acids, flavonoids, benzoxazinoids and volatile compounds, all of which contributed to its medicinal properties. The biological potential of this plant underlines diuretic, antiurolithiatic, anti-inflammatory, antioxidant and also antidiabetic qualities with molecular insights showing synergistic interactions across many compound classes. The current reported data notably confirmed its potential in lowering renal calculi and alleviating associated symptoms; however, the findings remain limited. E. repens’ medicinal potential is further confirmed by its historical application as an herbal tea and aqueous preparation, which clearly indicates its favorable safety profile. Along with this, from many encouraging results, there exist considerable deficiencies in standardization, clinical validation and also mechanistic clarification. This review highlights the necessity for careful studies to determine the therapeutic efficiency, enhance formulation and promote E. repens as a scientifically therapeutic agent.
Keywords: Elymus repens (L.); phytochemistry; pharmacological effects; diuretic activity; antiurolithiatic; urinary tract disorder Elymus repens (L.); phytochemistry; pharmacological effects; diuretic activity; antiurolithiatic; urinary tract disorder
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MDPI and ACS Style

Saparkhanovich, Z.K.; Asilbekovna, S.E.; Ilyasovna, T.M.; Mutalievna, A.R.; Kasymbekovna, S.Z.; Zhanburbaevna, U.G.; Dauletkyzy, S.Z.; Beybitkyzy, M.A.; Yermekuly, K.N.; Zulpidinovich, A.M.; et al. Elymus repens (L.) Gould Phytochemistry Pharmacological Activities and Therapeutic Potential with Future Perspectives. Int. J. Mol. Sci. 2026, 27, 4928. https://doi.org/10.3390/ijms27114928

AMA Style

Saparkhanovich ZK, Asilbekovna SE, Ilyasovna TM, Mutalievna AR, Kasymbekovna SZ, Zhanburbaevna UG, Dauletkyzy SZ, Beybitkyzy MA, Yermekuly KN, Zulpidinovich AM, et al. Elymus repens (L.) Gould Phytochemistry Pharmacological Activities and Therapeutic Potential with Future Perspectives. International Journal of Molecular Sciences. 2026; 27(11):4928. https://doi.org/10.3390/ijms27114928

Chicago/Turabian Style

Saparkhanovich, Zhakipbekov Kairat, Serikbayeva Elmira Asilbekovna, Tleubayeva Meruyert Ilyasovna, Anarbayeva Rabiga Mutalievna, Shimirova Zhanar Kasymbekovna, Umurzakhova Galiya Zhanburbaevna, Seitova Zhanerke Dauletkyzy, Mukanova Arailym Beybitkyzy, Konash Nyshanbay Yermekuly, Ashirov Murat Zulpidinovich, and et al. 2026. "Elymus repens (L.) Gould Phytochemistry Pharmacological Activities and Therapeutic Potential with Future Perspectives" International Journal of Molecular Sciences 27, no. 11: 4928. https://doi.org/10.3390/ijms27114928

APA Style

Saparkhanovich, Z. K., Asilbekovna, S. E., Ilyasovna, T. M., Mutalievna, A. R., Kasymbekovna, S. Z., Zhanburbaevna, U. G., Dauletkyzy, S. Z., Beybitkyzy, M. A., Yermekuly, K. N., Zulpidinovich, A. M., & Mukhankyzy, Z. G. (2026). Elymus repens (L.) Gould Phytochemistry Pharmacological Activities and Therapeutic Potential with Future Perspectives. International Journal of Molecular Sciences, 27(11), 4928. https://doi.org/10.3390/ijms27114928

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