Preimplantation Genetic Testing (PGT) to Reduce the Risk for GBA-Related Parkinson’s Disease: Expanding the Applications for Embryo Selection
Abstract
1. Introduction
1.1. Gaucher Disease
1.2. Prenatal Genetic Counseling for GD Patients and Carriers for the Risk of PD in the Fetus
1.3. “Manifesting Heterozygotes”: Risks Associated with Carrying One Mutation of Autosomal Recessive Disorders
2. Case Report
2.1. Ovarian Stimulation and Egg Retrieval
2.2. Blastomere Biopsy, ICSI, and Embryo Cultures
2.3. Molecular Analysis
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Zuckerman, S.; Zimran, A.; Szer, J.; Revel-Vilk, S.; Altarescu, G. Preimplantation Genetic Testing (PGT) to Reduce the Risk for GBA-Related Parkinson’s Disease: Expanding the Applications for Embryo Selection. Int. J. Mol. Sci. 2025, 26, 912. https://doi.org/10.3390/ijms26030912
Zuckerman S, Zimran A, Szer J, Revel-Vilk S, Altarescu G. Preimplantation Genetic Testing (PGT) to Reduce the Risk for GBA-Related Parkinson’s Disease: Expanding the Applications for Embryo Selection. International Journal of Molecular Sciences. 2025; 26(3):912. https://doi.org/10.3390/ijms26030912
Chicago/Turabian StyleZuckerman, Shachar, Ari Zimran, Jeff Szer, Shoshana Revel-Vilk, and Gheona Altarescu. 2025. "Preimplantation Genetic Testing (PGT) to Reduce the Risk for GBA-Related Parkinson’s Disease: Expanding the Applications for Embryo Selection" International Journal of Molecular Sciences 26, no. 3: 912. https://doi.org/10.3390/ijms26030912
APA StyleZuckerman, S., Zimran, A., Szer, J., Revel-Vilk, S., & Altarescu, G. (2025). Preimplantation Genetic Testing (PGT) to Reduce the Risk for GBA-Related Parkinson’s Disease: Expanding the Applications for Embryo Selection. International Journal of Molecular Sciences, 26(3), 912. https://doi.org/10.3390/ijms26030912