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Article
Peer-Review Record

Changes in Gut Microbiota According to Disease Severity in a Lupus Mouse Model

Int. J. Mol. Sci. 2025, 26(3), 1006; https://doi.org/10.3390/ijms26031006
by Eui-Jeong Han, Ji-Seon Ahn, Yu-Jin Choi, Da-Hye Kim and Hea-Jong Chung *
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2025, 26(3), 1006; https://doi.org/10.3390/ijms26031006
Submission received: 30 December 2024 / Revised: 15 January 2025 / Accepted: 23 January 2025 / Published: 24 January 2025
(This article belongs to the Special Issue Animal Gut Microbial Metagenome)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

See the file

Comments for author File: Comments.pdf

Author Response

The attached document contains a more detailed answer.

Author Response File: Author Response.docx

Reviewer 2 Report

Comments and Suggestions for Authors

A manuscript submitted by Han and colleagues emphasizes the critical role of gut microbiota dysbiosis and immune dysregulation in lupus pathogenesis, with severe lupus linked to a reduction in beneficial microbes and an increase in pathogenic species. The study suggests that these microbial imbalances may drive disease progression by impairing regulatory T cell function and enhancing B and T cell activation, highlighting potential biomarkers and therapeutic targets for systemic lupus erythematosus (SLE). The manuscript is interesting and suitable for publication; however, the authors should address a few minor points for clarity:

  • Please provide the full form and a one-sentence introduction of the MRL/lpr mouse model and CyTOF analysis in the abstract.
  • Expand on the background of systemic lupus erythematosus (SLE) in the introduction section.

These clarifications will enhance the manuscript’s overall interpretation and accessibility.

Author Response

The attached document contains a more detailed answer

Author Response File: Author Response.docx

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