Changes in Gut Microbiota According to Disease Severity in a Lupus Mouse Model
Round 1
Reviewer 1 Report
Comments and Suggestions for AuthorsSee the file
Comments for author File: Comments.pdf
Author Response
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Author Response File: Author Response.docx
Reviewer 2 Report
Comments and Suggestions for AuthorsA manuscript submitted by Han and colleagues emphasizes the critical role of gut microbiota dysbiosis and immune dysregulation in lupus pathogenesis, with severe lupus linked to a reduction in beneficial microbes and an increase in pathogenic species. The study suggests that these microbial imbalances may drive disease progression by impairing regulatory T cell function and enhancing B and T cell activation, highlighting potential biomarkers and therapeutic targets for systemic lupus erythematosus (SLE). The manuscript is interesting and suitable for publication; however, the authors should address a few minor points for clarity:
- Please provide the full form and a one-sentence introduction of the MRL/lpr mouse model and CyTOF analysis in the abstract.
- Expand on the background of systemic lupus erythematosus (SLE) in the introduction section.
These clarifications will enhance the manuscript’s overall interpretation and accessibility.
Author Response
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Author Response File: Author Response.docx