Correction: Meinarovich et al. Diagnosis of Secondary Bacterial Meningitis via Aromatic Metabolites and Biomarkers in Cerebrospinal Fluid. Int. J. Mol. Sci. 2025, 26, 10522
Reference
- Meinarovich, P.A.; Sorokina, E.A.; Beloborodova, N.V.; Pautova, A.K. Diagnosis of Secondary Bacterial Meningitis via Aromatic Metabolites and Biomarkers in Cerebrospinal Fluid. Int. J. Mol. Sci. 2025, 26, 10522. [Google Scholar] [CrossRef] [PubMed]
| Parameter | Reference Values | Cohort #1 | Cohort #2 | p Cohorts #1 and #2 | p 1.1 and 2.1 | p 1.2 and 2.2 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All Samples (n = 77) | Group 1.1 with Secondary Meningitis (n = 21) | Group 1.2 Without Secondary Meningitis (n = 56) | p 1.1 and 1.2 | All Samples (n = 19) | Group 2.1 with Secondary Meningitis (n = 12) | Group 2.2 Without Secondary Meningitis (n = 7) | p 2.1 and 2.2 | |||||
| Leucocyte count, cells/mm3 | 2–8 | 11 (3, 96) | 733 (139, 2000) | 6 (2, 18) | <0.001 | 163 (18, 710) | 258 (136, 866) | 14 (5, 88) | 0.21 | 0.27 | 0.62 | <0.001 |
| Lymphocytes, % | 90–95 | 61 (30, 94) | 11 (5, 36) | 75 (54, 100) | <0.001 | 4 (3, 6) | 4 (3, 8) | 4 (3, 5) | 0.55 | <0.001 | 0.08 | <0.001 |
| Neutrophils, % | 3–5 | 47 (25, 68) | 84 (69, 92) | 40 (22, 50) | <0.001 | 88 (44, 96) | 96 (87, 97) | 37 (11, 63) | <0.001 | <0.001 | 0.31 | 0.57 |
| Protein, g/L | 0.1–0.3 | 0.7 (0.5, 1.2) | 1.6 (0.6, 4.5) | 0.7 (0.5, 1.0) | <0.001 | 2.6 (1.2, 4.2) | 3.6 (2.4, 4.7) | 1.2 (0.5, 2.2) | 0.06 | <0.001 | 0.36 | 0.03 |
| Glucose, mmol/L | 2.8–3.9 | 3.1 (2.2, 3.8) | 0.6 (0.2, 3.5) | 3.2 (2.6, 3.8) | 0.12 | 2.6 (2.2, 3.5) | 2.2 (1.9, 2.7) | 3.7 (3.3, 4.2) | <0.001 | 0.42 | 0.99 | 0.78 |
| IL-6, pg/mL | 1.5 (1.0, 2.2) [23] | 71 (10, 897) | 3228 (104, 5000) | 42 (7, 234) | <0.001 | 2336 (420, 5000) | 4017 (1455, 5000) | 271 (144, 3371) | 0.19 | <0.001 | 0.46 | 0.03 |
| NSE, ng/mL | 17.3 ± 4.6 [24] | 1.6 (0.9, 3.2) | 2.0 (1.3, 9.3) | 1.3 (0.7, 2.9) | 0.06 | 12.1 (5.0, 37.2) | 20.5 (9.0, 35.7) | 5.0 (3.3, 64.7) | 0.7 | 0.14 | 0.4 | <0.001 |
| S100, μg/L | 1.4 ± 0.5 [25] | 0.8 (0.4, 3.3) | 3.7 (0.7, 18.0) | 0.6 (0.3, 1.2) | <0.001 | 6.5 (2.5, 23.1) | 5.5 (2.3, 26.0) | 9.2 (3.2, 19.6) | 0.98 | <0.001 | 0.7 | <0.001 |
| p-HPhLA, nmol/L | 237 (196, 319) [26] | 633 (370, 1246) | 2750 (1734, 4206) | 491 (281, 840) | <0.001 | 925 (533, 1485) | 1172 (861, 1726) | 522 (424, 725) | 0.46 | 0.7 | 0.03 | 0.1 |
| p-HBA, nmol/L | no data | 33 (23, 61) | 35 (23, 99) | 32 (22, 60) | 0.26 | 30 (17, 41) | 22 (14, 36) | 35 (33, 41) | 0.38 | 0.32 | 0.31 | 0.7 |
| p-HPhAA, nmol/L | no data | 223 (101, 469) | 906 (362, 3167) | 152 (77, 278) | 0.03 | 100 (60, 191) | 92 (66, 233) | 103 (60, 138) | 0.7 | 0.46 | 0.32 | 0.79 |
| PhLA, nmol/L | no data | 67 (43, 173) | 538 (361, 736) | 52 (36, 77) | <0.001 | 100 (59, 131) | 108 (94, 145) | 47 (35, 68) | 0.26 | 0.57 | 0.16 | 0.43 |
| 5HIAA, nmol/L | 71 (55, 102) [26] | 112 (22, 224) | 162 (85, 306) | 72 (<20, 212) | 0.35 | 122 (81, 204) | 143 (103, 215) | 72 (62, 146) | 0.91 | 0.87 | 0.77 | 0.93 |
| 3ILA, nmol/L | 9 (7–12) [26] | 11 (4, 27) | 202 (22, 472) | 5 (3, 15) | <0.001 | 25 (18, 85) | 60 (25, 93) | 10 (6, 18) | 0.39 | 0.95 | 0.26 | 0.03 |
| 3ICA, nmol/L | no data | 11 (6, 14) | 12 (11, 20) | 8 (6, 13) | 0.03 | 8 (6, 10) | 8 (7, 11) | 5 (4, 9) | 0.7 | 0.47 | 0.17 | 0.38 |
| 3IAA, nmol/L | 20 (14–32) [26] | 39 (22, 79) | 96 (47, 204) | 26 (18, 44) | 0.12 | 71 (43, 118) | 73 (65, 88) | 47 (35, 177) | 0.47 | 0.14 | 0.6 | 0.03 |
| 3IPA, nmol/L | 0.11 ± 0.02 [10] | <2 (<2, 4) | 2 (<2, 4) | <2 (<2, 4) | <0.001 | 9 (3, 15) | 9 (4, 16) | 2 (<2, 14) | 0.56 | 0.27 | 0.88 | <0.001 |
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Meinarovich, P.A.; Sorokina, E.A.; Beloborodova, N.V.; Pautova, A.K. Correction: Meinarovich et al. Diagnosis of Secondary Bacterial Meningitis via Aromatic Metabolites and Biomarkers in Cerebrospinal Fluid. Int. J. Mol. Sci. 2025, 26, 10522. Int. J. Mol. Sci. 2025, 26, 11856. https://doi.org/10.3390/ijms262411856
Meinarovich PA, Sorokina EA, Beloborodova NV, Pautova AK. Correction: Meinarovich et al. Diagnosis of Secondary Bacterial Meningitis via Aromatic Metabolites and Biomarkers in Cerebrospinal Fluid. Int. J. Mol. Sci. 2025, 26, 10522. International Journal of Molecular Sciences. 2025; 26(24):11856. https://doi.org/10.3390/ijms262411856
Chicago/Turabian StyleMeinarovich, Petr A., Ekaterina A. Sorokina, Natalia V. Beloborodova, and Alisa K. Pautova. 2025. "Correction: Meinarovich et al. Diagnosis of Secondary Bacterial Meningitis via Aromatic Metabolites and Biomarkers in Cerebrospinal Fluid. Int. J. Mol. Sci. 2025, 26, 10522" International Journal of Molecular Sciences 26, no. 24: 11856. https://doi.org/10.3390/ijms262411856
APA StyleMeinarovich, P. A., Sorokina, E. A., Beloborodova, N. V., & Pautova, A. K. (2025). Correction: Meinarovich et al. Diagnosis of Secondary Bacterial Meningitis via Aromatic Metabolites and Biomarkers in Cerebrospinal Fluid. Int. J. Mol. Sci. 2025, 26, 10522. International Journal of Molecular Sciences, 26(24), 11856. https://doi.org/10.3390/ijms262411856

