Correction: Enríquez-Rodríguez et al. Metabolomic Signatures Predict Seven-Year Mortality in Clinically Stable COPD Patients. Int. J. Mol. Sci. 2025, 26, 6373

Enríquez-Rodríguez, César Jessé; Agranovich, Bella; Pascual-Guàrdia, Sergi; Faner, Rosa; Camps-Ubach, Ramon; Castro-Acosta, Ady; López-Campos, José Luis; Peces-Barba, Germán; Seijo, Luis; Caguana-Vélez, Oswaldo Antonio; Rodríguez-Chiaradia, Diego; Barreiro, Esther; Monsó, Eduard; Cosío, Borja G.; Abramovich, Ifat; Agustí, Alvar; Casadevall, Carme; Gea, Joaquim; on behalf of the BIOMEPOC Group,

doi:10.3390/ijms262010217

Open AccessCorrection

Correction: Enríquez-Rodríguez et al. Metabolomic Signatures Predict Seven-Year Mortality in Clinically Stable COPD Patients. Int. J. Mol. Sci. 2025, 26, 6373

by

César Jessé Enríquez-Rodríguez

^1,2,3,†

,

Bella Agranovich

⁴,

Sergi Pascual-Guàrdia

^1,2,3,

Rosa Faner

^3,5

,

Ramon Camps-Ubach

^1,2,3

,

Ady Castro-Acosta

⁶,

José Luis López-Campos

^3,7,

Germán Peces-Barba

^3,8

,

Luis Seijo

^3,8,9,

Oswaldo Antonio Caguana-Vélez

^1,2

,

Diego Rodríguez-Chiaradia

^1,2,3

,

Esther Barreiro

^1,2,3,

Eduard Monsó

^3,10,

Borja G. Cosío

^3,11

,

Ifat Abramovich

⁴,

Alvar Agustí

^3,5,

Carme Casadevall

^1,2,3,‡

,

Joaquim Gea

^1,2,3,*,‡ and

on behalf of the BIOMEPOC Group

^§

¹

Hospital del Mar Research Institute, Servei de Pneumologia, Hospital del Mar, 08003 Barcelona, Spain

²

MELIS Department, Universitat Pompeu Fabra, 08003 Barcelona, Spain

³

Centro de Investigación Biomédica en Red, Área de Enfermedades Respiratorias (CIBERES), ISCiii, 28029 Madrid, Spain

⁴

The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 3525433, Israel

⁵

Servei de Pneumologia (Institut Clínic de Respiratori), Hospital Clínic—Fundació Clínic per la Recerca Biomèdica, Universitat de Barcelona, 08036 Barcelona, Spain

⁶

Servicio de Neumología, Hospital 12 de Octubre, 28041 Madrid, Spain

⁷

Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, 41012 Sevilla, Spain

⁸

Servicio de Neumología, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, 28049 Madrid, Spain

⁹

Servicio de Neumología, Clínica Universidad de Navarra, 28027 Madrid, Spain

¹⁰

Fundació Institut d’Investigació i Innovació Parc Taulí (I3PT), 08208 Sabadell, Spain

¹¹

Servicio de Neumología, Hospital Son Espases, Institut d’Investigació Sanitària Illes Balears (IdISBa), Universitat de les Illes Balears, 07120 Palma, Spain

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^*

Author to whom correspondence should be addressed.

^†

This author is a recipient of a Predoctoral Grant PFIS from ISCIII, co-funded by the European Union (ref. FI22/00003).

^‡

These authors contributed equally as the senior author of this work.

^§

See the Appendix A for members of the group.

Int. J. Mol. Sci. 2025, 26(20), 10217; https://doi.org/10.3390/ijms262010217

Submission received: 1 October 2025 / Accepted: 7 October 2025 / Published: 21 October 2025

(This article belongs to the Special Issue Molecular Mechanisms and Therapies of Chronic Obstructive Pulmonary Disease)

Download Versions Notes

Error in Table 4

In the original publication, the authors identified a mistake in Table 4 as published [1]: the values in Table 4 were duplicated from Table 3. The corrected Table 4 appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

Appendix A

Members of the BIOMEPOC group (in alphabetical order): Mireia Admetlló, Alvar Agustí, Carlos Alvarez-Martínez, Esther Barreiro, Oswaldo Antonio Caguana, Carme Casadevall, Ferran Casals, Robert Castelo, Ady Castro-Acosta, Rocío Córdova, Borja G Cosío, Rosa Faner, Laura I Furlong, Marian García, José G. González-García, Carmen Hernández-Carcereny, José Luis López-Campos, Eduardo Márquez, Eduard Monsó, Concepción Montón, Miren Josune Ormaza, Alexandre Palou, Sergi Pascual, Germán Peces-Barba, Pau Puigdevall, Diego A. Rodríguez-Chiaradia, Ferran Sanz, Luis Seijo, Montserrat Torà, Yolanda Torralba, and Carles Vilaplana.

Reference

Enríquez-Rodríguez, C.J.; Agranovich, B.; Pascual-Guàrdia, S.; Faner, R.; Camps-Ubach, R.; Castro-Acosta, A.; López-Campos, J.L.; Peces-Barba, G.; Seijo, L.; Caguana-Vélez, O.A.; et al. Metabolomic Signatures Predict Seven-Year Mortality in Clinically Stable COPD Patients. Int. J. Mol. Sci. 2025, 26, 6373. [Google Scholar] [CrossRef] [PubMed]

Table 4. Comparison of prediction models using conventional DAMs versus AI-based free metabolite selection combined with FEV₁ integration.

	Conventional + FEV₁	AI Free Choice + FEV₁
Fitting
Sensitivity–Specificity–MCC	1.00	1.00
Coverage	1.00	1.00
Prediction
Sensitivity	0.83	1.00
Specificity	1.00	0.92
MCC	0.83	0.92
Coverage	0.85	0.96
PPV (rep/our)	1.00/1.00	0.92/0.86
NPV (rep/our)	0.87/0.93	1.00/1.00
Accuracy (rep/our)	0.92/0.95	0.96/0.95

PPV: NPV and accuracy were calculated based on either (a) the mortality observed in our COPD cohort (32%) [our] or (b) the mortality rate previously reported [rep] in the Spanish COPD population (47%) [11], which aligns with mortality predictions derived from the 3CIA initiative detailed in Appendix B [6,12]. Abbreviations: MCC: Matthews correlation coefficient; PPV: positive predicted value; NPV: negative predicted value; rep: reported mortality; our: our own mortality; AI: artificial intelligence.

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© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MDPI and ACS Style

Enríquez-Rodríguez, C.J.; Agranovich, B.; Pascual-Guàrdia, S.; Faner, R.; Camps-Ubach, R.; Castro-Acosta, A.; López-Campos, J.L.; Peces-Barba, G.; Seijo, L.; Caguana-Vélez, O.A.; et al. Correction: Enríquez-Rodríguez et al. Metabolomic Signatures Predict Seven-Year Mortality in Clinically Stable COPD Patients. Int. J. Mol. Sci. 2025, 26, 6373. Int. J. Mol. Sci. 2025, 26, 10217. https://doi.org/10.3390/ijms262010217

AMA Style

Enríquez-Rodríguez CJ, Agranovich B, Pascual-Guàrdia S, Faner R, Camps-Ubach R, Castro-Acosta A, López-Campos JL, Peces-Barba G, Seijo L, Caguana-Vélez OA, et al. Correction: Enríquez-Rodríguez et al. Metabolomic Signatures Predict Seven-Year Mortality in Clinically Stable COPD Patients. Int. J. Mol. Sci. 2025, 26, 6373. International Journal of Molecular Sciences. 2025; 26(20):10217. https://doi.org/10.3390/ijms262010217

Chicago/Turabian Style

Enríquez-Rodríguez, César Jessé, Bella Agranovich, Sergi Pascual-Guàrdia, Rosa Faner, Ramon Camps-Ubach, Ady Castro-Acosta, José Luis López-Campos, Germán Peces-Barba, Luis Seijo, Oswaldo Antonio Caguana-Vélez, and et al. 2025. "Correction: Enríquez-Rodríguez et al. Metabolomic Signatures Predict Seven-Year Mortality in Clinically Stable COPD Patients. Int. J. Mol. Sci. 2025, 26, 6373" International Journal of Molecular Sciences 26, no. 20: 10217. https://doi.org/10.3390/ijms262010217

APA Style

Enríquez-Rodríguez, C. J., Agranovich, B., Pascual-Guàrdia, S., Faner, R., Camps-Ubach, R., Castro-Acosta, A., López-Campos, J. L., Peces-Barba, G., Seijo, L., Caguana-Vélez, O. A., Rodríguez-Chiaradia, D., Barreiro, E., Monsó, E., Cosío, B. G., Abramovich, I., Agustí, A., Casadevall, C., Gea, J., & on behalf of the BIOMEPOC Group. (2025). Correction: Enríquez-Rodríguez et al. Metabolomic Signatures Predict Seven-Year Mortality in Clinically Stable COPD Patients. Int. J. Mol. Sci. 2025, 26, 6373. International Journal of Molecular Sciences, 26(20), 10217. https://doi.org/10.3390/ijms262010217

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Correction: Enríquez-Rodríguez et al. Metabolomic Signatures Predict Seven-Year Mortality in Clinically Stable COPD Patients. Int. J. Mol. Sci. 2025, 26, 6373

Error in Table 4

Appendix A

Reference

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