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Correction to Int. J. Mol. Sci. 2023, 24(19), 14693.
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Correction

Correction: Liao et al. Involvement of IL-1β-Mediated Necroptosis in Neurodevelopment Impairment after Neonatal Sepsis in Rats. Int. J. Mol. Sci. 2023, 24, 14693

by
Zhimin Liao
,
Qing Zhu
and
Han Huang
*
Department of Anesthesiology and Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital of Sichuan University, Chengdu 610041, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(17), 8513; https://doi.org/10.3390/ijms26178513
Submission received: 25 August 2025 / Accepted: 28 August 2025 / Published: 2 September 2025
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Browse Figures
Review Reports Versions Notes
In the original publication [1], there was a mistake in Figures 2C and 8F as published. In Figure 2C, the trace for group LPS was incorrect as it was the same as that in group Con. In Figure 8F, the representative blotting band for MLKL was incorrectly selected, which belongs to another publication from us [2] (cited as reference 42 in this IJMS publication). We were preparing these two original manuscripts at the same time, and these two sets of bands were of high similarity. We apologize for these unintentional errors. The corrected Figure 2C and Figure 8F appear below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

References

  1. Liao, Z.; Zhu, Q.; Huang, H. Involvement of IL-1β-Mediated Necroptosis in Neurodevelopment Impairment after Neonatal Sepsis in Rats. Int. J. Mol. Sci. 2023, 24, 14693. [Google Scholar] [CrossRef] [PubMed]
  2. Liao, Z.; Ou, X.; Zhou, C.; Ma, D.; Zhao, H.; Huang, H. Xenon attenuated neonatal lipopolysaccharide exposure induced neuronal necroptosis and subsequently improved cognition in juvenile rats. Front. Pharmacol. 2022, 13, 1002920. [Google Scholar] [CrossRef] [PubMed]
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Figure 2. Intraperitoneal LPS injection on P3 led to long-term cognitive impairment. (A) The survival rates of rat pups following LPS injection (n = 16). (B) The increase in body weight in rat pups (n = 16 in the control group, n = 11 in the LPS group). (C) Representative traces of the MWM test. (D) The mean velocity of swimming during the MWM test. (E) Percentage of time spent in the target quadrant. (F) Number of platform crossings. (G) Latency time to find the area for the platform (n = 16 in the control group, n = 11 in the LPS group for (D–G)). (H) The freezing time of rats in the context test. (I) The freezing time of rats in the cue tone FC test (n = 16 in the control group, n = 11 in the LPS group for (H,I)). (J) The correlation between hippocampal IL-1β level and freezing time of context test (n = 6). LPS: lipopolysaccharide; MWM: Morris water maze; FC: fear conditioning. Data are expressed as the mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001, n.s.: no significance.
Figure 2. Intraperitoneal LPS injection on P3 led to long-term cognitive impairment. (A) The survival rates of rat pups following LPS injection (n = 16). (B) The increase in body weight in rat pups (n = 16 in the control group, n = 11 in the LPS group). (C) Representative traces of the MWM test. (D) The mean velocity of swimming during the MWM test. (E) Percentage of time spent in the target quadrant. (F) Number of platform crossings. (G) Latency time to find the area for the platform (n = 16 in the control group, n = 11 in the LPS group for (D–G)). (H) The freezing time of rats in the context test. (I) The freezing time of rats in the cue tone FC test (n = 16 in the control group, n = 11 in the LPS group for (H,I)). (J) The correlation between hippocampal IL-1β level and freezing time of context test (n = 6). LPS: lipopolysaccharide; MWM: Morris water maze; FC: fear conditioning. Data are expressed as the mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001, n.s.: no significance.
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Figure 8. Inhibiting necroptosis reduced impairment of neuron development and synaptic function after neonatal LPS injection. (A) Western blotting with statistics for expression of GAP-43 (B), NeuN (C), PSD-95 (D), and SYN (E) (n = 6). (F) Western blotting with statistics for expression of RIP1 (G), RIP3 (H), and MLKL (I) (n = 6). (J) IL-1β mRNA expression in hippocampus after NEC1 treatment (n = 6). LPS: lipopolysaccharide; DMSO: dimethyl sulfoxide; NEC1: Necrostatin-1. Data are expressed as the mean ± SD. * p < 0.05, ** p < 0.01.
Figure 8. Inhibiting necroptosis reduced impairment of neuron development and synaptic function after neonatal LPS injection. (A) Western blotting with statistics for expression of GAP-43 (B), NeuN (C), PSD-95 (D), and SYN (E) (n = 6). (F) Western blotting with statistics for expression of RIP1 (G), RIP3 (H), and MLKL (I) (n = 6). (J) IL-1β mRNA expression in hippocampus after NEC1 treatment (n = 6). LPS: lipopolysaccharide; DMSO: dimethyl sulfoxide; NEC1: Necrostatin-1. Data are expressed as the mean ± SD. * p < 0.05, ** p < 0.01.
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MDPI and ACS Style

Liao, Z.; Zhu, Q.; Huang, H. Correction: Liao et al. Involvement of IL-1β-Mediated Necroptosis in Neurodevelopment Impairment after Neonatal Sepsis in Rats. Int. J. Mol. Sci. 2023, 24, 14693. Int. J. Mol. Sci. 2025, 26, 8513. https://doi.org/10.3390/ijms26178513

AMA Style

Liao Z, Zhu Q, Huang H. Correction: Liao et al. Involvement of IL-1β-Mediated Necroptosis in Neurodevelopment Impairment after Neonatal Sepsis in Rats. Int. J. Mol. Sci. 2023, 24, 14693. International Journal of Molecular Sciences. 2025; 26(17):8513. https://doi.org/10.3390/ijms26178513

Chicago/Turabian Style

Liao, Zhimin, Qing Zhu, and Han Huang. 2025. "Correction: Liao et al. Involvement of IL-1β-Mediated Necroptosis in Neurodevelopment Impairment after Neonatal Sepsis in Rats. Int. J. Mol. Sci. 2023, 24, 14693" International Journal of Molecular Sciences 26, no. 17: 8513. https://doi.org/10.3390/ijms26178513

APA Style

Liao, Z., Zhu, Q., & Huang, H. (2025). Correction: Liao et al. Involvement of IL-1β-Mediated Necroptosis in Neurodevelopment Impairment after Neonatal Sepsis in Rats. Int. J. Mol. Sci. 2023, 24, 14693. International Journal of Molecular Sciences, 26(17), 8513. https://doi.org/10.3390/ijms26178513

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