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Volume 26
Issue 17
10.3390/ijms26178196
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Reactivity of Autologous Serum IgG to Gut Microbes in Pediatric Ulcerative Colitis

by
Nafisa Tabassum
1,
Haruyuki Nakayama-Imaohji
1,
Emmanuel Munyeshyaka
1,
Ayano Tada
1,
Takeo Kondo
2,
Sonoko Kondo
2,
Takashi Kusaka
2 and
Tomomi Kuwahara
1,*
1
Department of Microbiology, Faculty of Medicine, Kagawa University, 1750-1 Miki-cho, Kita-gun, Takamatsu 761-0793, Kagawa, Japan
2
Department of Pediatrics, Faculty of Medicine, Kagawa University, 1750-1 Miki-cho, Kita-gun, Takamatsu 761-0793, Kagawa, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(17), 8196; https://doi.org/10.3390/ijms26178196 (registering DOI)
Submission received: 30 July 2025 / Revised: 21 August 2025 / Accepted: 21 August 2025 / Published: 23 August 2025
(This article belongs to the Special Issue Gut Microbiome Stability in Health and Disease)
Versions Notes

Abstract

Ulcerative colitis (UC) is caused by an excessive immune response to gut microbiota. A recent study reported that the population of IgG-coated gut microbes increases with disease severity in patients with UC, but the role of these IgG-coated microbes in UC pathology is unclear. Serum, feces and colonoscopic lavage fluids (CLFs) were collected from pediatric UC (n = 13) and non-inflammatory bowel disease (IBD) patients (n = 15). Gut microbes were isolated from feces. Serum IgG reactivity to microbial cells and CLF-derived proteins was evaluated by Western blotting. Complement activation by the bacteria–IgG complexes was also assessed. Serum IgG reactivity to gut microbial extracts was highly variable in patients with active UC and increased with mucosal inflammation. IgG reactivity and clinical condition were inversely associated depending on disease activity. Non-IBD patients showed a similar degree of serum IgG response as that seen for patients whose UC was in remission. Lactobacillaceae bound higher amounts of IgG than other gut microbes tested and absorbed IgG to other bacteria. Lacticaseibacillus paracasei suppressed complement activation by Escherichia coli–IgG immune complexes. Appropriate IgG responses to luminal microbes might play a key role in gut microbiota stability by reducing excessive mucosal inflammation.
Keywords: serum IgG; pediatric UC; gut microbes; colonoscopy; Escherichia coli; Lactobacillus spp. serum IgG; pediatric UC; gut microbes; colonoscopy; Escherichia coli; Lactobacillus spp.

Share and Cite

MDPI and ACS Style

Tabassum, N.; Nakayama-Imaohji, H.; Munyeshyaka, E.; Tada, A.; Kondo, T.; Kondo, S.; Kusaka, T.; Kuwahara, T. Reactivity of Autologous Serum IgG to Gut Microbes in Pediatric Ulcerative Colitis. Int. J. Mol. Sci. 2025, 26, 8196. https://doi.org/10.3390/ijms26178196

AMA Style

Tabassum N, Nakayama-Imaohji H, Munyeshyaka E, Tada A, Kondo T, Kondo S, Kusaka T, Kuwahara T. Reactivity of Autologous Serum IgG to Gut Microbes in Pediatric Ulcerative Colitis. International Journal of Molecular Sciences. 2025; 26(17):8196. https://doi.org/10.3390/ijms26178196

Chicago/Turabian Style

Tabassum, Nafisa, Haruyuki Nakayama-Imaohji, Emmanuel Munyeshyaka, Ayano Tada, Takeo Kondo, Sonoko Kondo, Takashi Kusaka, and Tomomi Kuwahara. 2025. "Reactivity of Autologous Serum IgG to Gut Microbes in Pediatric Ulcerative Colitis" International Journal of Molecular Sciences 26, no. 17: 8196. https://doi.org/10.3390/ijms26178196

APA Style

Tabassum, N., Nakayama-Imaohji, H., Munyeshyaka, E., Tada, A., Kondo, T., Kondo, S., Kusaka, T., & Kuwahara, T. (2025). Reactivity of Autologous Serum IgG to Gut Microbes in Pediatric Ulcerative Colitis. International Journal of Molecular Sciences, 26(17), 8196. https://doi.org/10.3390/ijms26178196

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