This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Open AccessReview
When Genes Wear Marks: Epigenomic Modulation in the Development and Progression of Obesity
by
Alexandra F. Nikolaeva
Alexandra F. Nikolaeva 1,*,
Marina V. Nemtsova
Marina V. Nemtsova 2,
Anna V. Pustovalova
Anna V. Pustovalova 1
and
Vladimir O. Sigin
Vladimir O. Sigin 1
1
Research Centre for Medical Genetics, 115522 Moscow, Russia
2
Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(16), 8067; https://doi.org/10.3390/ijms26168067 (registering DOI)
Submission received: 4 August 2025
/
Revised: 19 August 2025
/
Accepted: 19 August 2025
/
Published: 20 August 2025
Abstract
Obesity represents a global medical and social challenge characterized by pathological accumulation of adipose tissue as a result of complex interactions among genetic, environmental, and epigenetic factors. Recent studies have highlighted the pivotal role of epigenetic mechanisms in the pathogenesis of this condition, including abnormal DNA methylation of metabolic genes, dysregulation of microRNAs, and chromatin remodeling. These modifications are reversible and can be modulated by dietary, behavioral, and pharmacological interventions. This review provides a comprehensive analysis of tissue-specific epigenetic alterations identified not only in adipocytes and hepatocytes but also in peripheral blood cells, offering promising opportunities for the development of novel diagnostic biomarkers and targeted epigenetic therapeutic strategies.
Share and Cite
MDPI and ACS Style
Nikolaeva, A.F.; Nemtsova, M.V.; Pustovalova, A.V.; Sigin, V.O.
When Genes Wear Marks: Epigenomic Modulation in the Development and Progression of Obesity. Int. J. Mol. Sci. 2025, 26, 8067.
https://doi.org/10.3390/ijms26168067
AMA Style
Nikolaeva AF, Nemtsova MV, Pustovalova AV, Sigin VO.
When Genes Wear Marks: Epigenomic Modulation in the Development and Progression of Obesity. International Journal of Molecular Sciences. 2025; 26(16):8067.
https://doi.org/10.3390/ijms26168067
Chicago/Turabian Style
Nikolaeva, Alexandra F., Marina V. Nemtsova, Anna V. Pustovalova, and Vladimir O. Sigin.
2025. "When Genes Wear Marks: Epigenomic Modulation in the Development and Progression of Obesity" International Journal of Molecular Sciences 26, no. 16: 8067.
https://doi.org/10.3390/ijms26168067
APA Style
Nikolaeva, A. F., Nemtsova, M. V., Pustovalova, A. V., & Sigin, V. O.
(2025). When Genes Wear Marks: Epigenomic Modulation in the Development and Progression of Obesity. International Journal of Molecular Sciences, 26(16), 8067.
https://doi.org/10.3390/ijms26168067
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details
here.
Article Metrics
Article Access Statistics
For more information on the journal statistics, click
here.
Multiple requests from the same IP address are counted as one view.