Next Article in Journal
Evaluating the Antitumor Potential of Cannabichromene, Cannabigerol, and Related Compounds from Cannabis sativa and Piper nigrum Against Malignant Glioma: An In Silico to In Vitro Approach
Next Article in Special Issue
Connecting the Dots: Mitochondrial Dysfunction, PCOS, and Insulin Resistance—Insights and Therapeutic Advances
Previous Article in Journal
Genomic Prediction and Heritability Estimation for Daughter Pregnancy Rate in U.S. Holstein Cows Using SNP, Epistasis and Haplotype Effects
Previous Article in Special Issue
Advances in Insulin Resistance—Molecular Mechanisms, Therapeutic Targets, and Future Directions
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 26
Issue 12
10.3390/ijms26125669
Review Report
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Severe Insulin Resistance Syndromes: Clinical Spectrum and Management

Int. J. Mol. Sci. 2025, 26(12), 5669; https://doi.org/10.3390/ijms26125669
by Monika Pliszka and Leszek Szablewski *
Reviewer 1:
Marek Bolanowski
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2025, 26(12), 5669; https://doi.org/10.3390/ijms26125669
Submission received: 14 May 2025 / Revised: 7 June 2025 / Accepted: 10 June 2025 / Published: 13 June 2025
(This article belongs to the Special Issue Advances in Insulin Resistance Research: 2nd Edition)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

This is a comprehensive overview of severe insulin resistance syndromes. The text of manuscript is very long but presentation is detailed. The authors must improve English and explain all abbreviations at first application in the text. In my opinion Table 1 should be divided in more ones.

New therapies like tirzepatide (dual GIP and GLP-1RA) and retatrutide (triple) should be discussed.

Other remarks are marked in the file

Comments for author File: Comments.pdf

Comments on the Quality of English Language

Medical English should be improved by native speaker

Author Response

Dear Reviewer, please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Comments and Suggestions for Authors

The review by Pliszka and Szablewski aims to provide a wide-ranging summary of SIRS, covering their pathophysiology, complications, prognosis and classification. It also includes a final paragraph on the various treatment options available.

Overall, this review offers an up-to-date, comprehensive overview of SIRS. However, several paragraphs need to be revised for grammar (e.g., 'cells fail to adequately respond to insulin').

Furthermore, the introduction is rather long, and some sentences are redundant. For example, ‘There are also some cases, that organs may develop resistance to insulin, causing affected normal insulin action and cells sensitive to insulin, do not respond to its levels in the body'.

'Severe insulin resistance syndromes' should always be abbreviated to 'SIRS' in the text, not just in the therapy and summary sections.

I suggest including a description of the other SIRS mentioned in Section 2.7.6 instead of only mentioning references.

Finally, although Table 1 is intended to summarise SIRS characteristics, it should be revised and streamlined, and columns should be added if necessary to include more information

Author Response

Dear reviewer, please see the attachment.

Author Response File: Author Response.docx

Back to TopTop