Next Article in Journal
Ankyloblepharon–Ectodermal Defects–Cleft Lip/Palate Syndrome-Linked p63 Mutations Disrupt Keratinocyte Proliferation and Survival Through Oxidative Stress and Impaired Slc7a11 Expression
Previous Article in Journal
Deciphering the Overlapping Immune Mechanism Between Depression and Breast Cancer
Previous Article in Special Issue
Capsaicin Reduces Obesity by Reducing Chronic Low-Grade Inflammation
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 26
Issue 11
10.3390/ijms26115230
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Withania somnifera and Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura Complex Attenuates Obesity in High-Fat-Diet-Induced Obese Mice

by
Seong-Hoo Park
1,†,
Jeongjin Park
2,†,
Eunhee Yoo
1,
Jaeeun Jung
1,
Mi-Ryeong Park
3,
Soyoung Kim
3,
Jong-Lae Kim
3,
Jong Wook Lee
3,
Ok-kyung Kim
2,* and
Minhee Lee
4,*
1
Clinical Nutrition Institute, Kyung Hee University, Seoul 02447, Republic of Korea
2
Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju 61186, Republic of Korea
3
HLscience Co., Ltd., Uiwang-si 16004, Republic of Korea
4
Department of Food Innovation and Health, Kyung Hee University, Yongin 17104, Republic of Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2025, 26(11), 5230; https://doi.org/10.3390/ijms26115230
Submission received: 21 April 2025 / Revised: 26 May 2025 / Accepted: 26 May 2025 / Published: 29 May 2025
(This article belongs to the Special Issue Natural Products in Obesity: Novel Strategies and Molecular Mechanisms: 2nd Edition)
Browse Figures
Review Reports Versions Notes

Abstract

This study aims to evaluate the anti-obesity effects of Ashwagandha (Withania somnifera, AS), Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura (C), and their combination (AS:C = 3:1, ASC) in high-fat-diet (HFD)-induced obese animal models. Key metabolic parameters, including body weight, lipid metabolism, adipogenesis, energy expenditure, and glucose homeostasis, were assessed. HFD-fed mice were supplemented with AS25, C25, or ASC at different concentrations (ASC25, ASC50, and ASC100). Body weight, food efficiency ratio (FER), organ and adipose tissue weights were measured. Serum biochemical markers, including lipid profiles, glucose, insulin, and liver enzymes, were analyzed. Western blot analysis was conducted to assess the expression of key proteins involved in adipogenesis, lipogenesis, lipolysis, and energy metabolism. ASC complex supplementation, particularly at higher doses (ASC100), significantly reduced body weight gain, liver weight, and total white adipose tissue (WAT) accumulation. ASC complex groups exhibited improved lipid profiles, with reductions in triglycerides, total cholesterol, and low-density lipoprotein (LDL). Serum glucose, insulin, and HbA1c levels were significantly reduced, suggesting improved insulin sensitivity. Western blot analysis revealed that ASC complex supplementation downregulated key adipogenic markers, including PPARγ, C/EBPα, and SREBP1c, while enhancing adiponectin levels. ASC complex also promoted energy metabolism by increasing the phosphorylation of AMPK and UCP1 expression, indicative of enhanced thermogenesis and lipid oxidation. ASC complex supplementation demonstrates a potent anti-obesity effect by modulating adipogenesis, lipid metabolism, and energy expenditure. The findings suggest that ASC complex could serve as a promising natural therapeutic strategy for obesity and metabolic disorders. Further research, including clinical trials, is warranted to validate its efficacy and safety in human populations.
Keywords: obesity; Ashwagandha (Withania somnifera); Gujeolcho; Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura obesity; Ashwagandha (Withania somnifera); Gujeolcho; Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura

Share and Cite

MDPI and ACS Style

Park, S.-H.; Park, J.; Yoo, E.; Jung, J.; Park, M.-R.; Kim, S.; Kim, J.-L.; Lee, J.W.; Kim, O.-k.; Lee, M. Withania somnifera and Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura Complex Attenuates Obesity in High-Fat-Diet-Induced Obese Mice. Int. J. Mol. Sci. 2025, 26, 5230. https://doi.org/10.3390/ijms26115230

AMA Style

Park S-H, Park J, Yoo E, Jung J, Park M-R, Kim S, Kim J-L, Lee JW, Kim O-k, Lee M. Withania somnifera and Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura Complex Attenuates Obesity in High-Fat-Diet-Induced Obese Mice. International Journal of Molecular Sciences. 2025; 26(11):5230. https://doi.org/10.3390/ijms26115230

Chicago/Turabian Style

Park, Seong-Hoo, Jeongjin Park, Eunhee Yoo, Jaeeun Jung, Mi-Ryeong Park, Soyoung Kim, Jong-Lae Kim, Jong Wook Lee, Ok-kyung Kim, and Minhee Lee. 2025. "Withania somnifera and Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura Complex Attenuates Obesity in High-Fat-Diet-Induced Obese Mice" International Journal of Molecular Sciences 26, no. 11: 5230. https://doi.org/10.3390/ijms26115230

APA Style

Park, S.-H., Park, J., Yoo, E., Jung, J., Park, M.-R., Kim, S., Kim, J.-L., Lee, J. W., Kim, O.-k., & Lee, M. (2025). Withania somnifera and Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura Complex Attenuates Obesity in High-Fat-Diet-Induced Obese Mice. International Journal of Molecular Sciences, 26(11), 5230. https://doi.org/10.3390/ijms26115230

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop