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Case Report
Peer-Review Record

Novel Ultrastructural Insights into the Clear-Cell Carcinoma of the Pancreas: A Case Report

Int. J. Mol. Sci. 2024, 25(8), 4313; https://doi.org/10.3390/ijms25084313
by Valentina Giansante 1, Luca Di Angelo 1, Chiara Calabrese 1, Paolo De Sanctis 1, Paolo Regi 2, Filippo Maria Martelli 2, Gianmarco Stati 1, Rossano Lattanzio 3,4, Saverio Alberti 5, Emanuela Guerra 1,4 and Roberta Di Pietro 1,6,*
Reviewer 1:
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2024, 25(8), 4313; https://doi.org/10.3390/ijms25084313
Submission received: 29 February 2024 / Accepted: 3 April 2024 / Published: 13 April 2024
(This article belongs to the Special Issue Therapeutic Targets in Pancreatic Cancer)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

I have carefully reviewed the manuscript submitted for consideration and appreciate the opportunity extended to me. It pertains to the description of an intriguing clinical case concerning a rare subtype of PDAC, namely Clear Cell Carcinoma of the Pancreas. The manuscript is well-written, albeit somewhat verbose, yet overall sufficiently comprehensible. Particularly commendable is the description, which, in my opinion, is meticulously detailed, accompanied by visually appealing immunohistochemical images. The references section is adequate. I believe the manuscript can be accepted for publication in its current form.

Reviewer 2 Report

Comments and Suggestions for Authors

In this report, the authors reported a rare kind of PADAC, clear cell primary adenocarcinoma of the pancreas (CCCP). Their histological examinations showed clear and abundant vacuoles in tumor cells, and further ultrastructural analysis by TEM revealed many mitochondria in the cytoplasm. These findings reveal new aspects of clear cell CCCP, including the accumulation of disrupted mitochondria. This extends our understanding of the nature of CCCP. In addition, the discussion thoroughly addresses the relative aspects of their observations and the current studies regarding CCCP.

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