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Review

Edaravone: A Novel Possible Drug for Cancer Treatment?

by
Elisa Duranti
,
Nicoletta Cordani
and
Chiara Villa
*
School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(3), 1633; https://doi.org/10.3390/ijms25031633
Submission received: 22 December 2023 / Revised: 18 January 2024 / Accepted: 25 January 2024 / Published: 29 January 2024
(This article belongs to the Special Issue Molecular Mechanism of Anti-cancer Drugs)

Abstract

Despite significant advancements in understanding the causes and progression of tumors, cancer remains one of the leading causes of death worldwide. In light of advances in cancer therapy, there has been a growing interest in drug repurposing, which involves exploring new uses for medications that are already approved for clinical use. One such medication is edaravone, which is currently used to manage patients with cerebral infarction and amyotrophic lateral sclerosis. Due to its antioxidant and anti-inflammatory properties, edaravone has also been investigated for its potential activities in treating cancer, notably as an anti-proliferative and cytoprotective drug against side effects induced by traditional cancer therapies. This comprehensive review aims to provide updates on the various applications of edaravone in cancer therapy. It explores its potential as a standalone antitumor drug, either used alone or in combination with other medications, as well as its role as an adjuvant to mitigate the side effects of conventional anticancer treatments.
Keywords: edaravone; oxidative stress; cancer edaravone; oxidative stress; cancer

Share and Cite

MDPI and ACS Style

Duranti, E.; Cordani, N.; Villa, C. Edaravone: A Novel Possible Drug for Cancer Treatment? Int. J. Mol. Sci. 2024, 25, 1633. https://doi.org/10.3390/ijms25031633

AMA Style

Duranti E, Cordani N, Villa C. Edaravone: A Novel Possible Drug for Cancer Treatment? International Journal of Molecular Sciences. 2024; 25(3):1633. https://doi.org/10.3390/ijms25031633

Chicago/Turabian Style

Duranti, Elisa, Nicoletta Cordani, and Chiara Villa. 2024. "Edaravone: A Novel Possible Drug for Cancer Treatment?" International Journal of Molecular Sciences 25, no. 3: 1633. https://doi.org/10.3390/ijms25031633

APA Style

Duranti, E., Cordani, N., & Villa, C. (2024). Edaravone: A Novel Possible Drug for Cancer Treatment? International Journal of Molecular Sciences, 25(3), 1633. https://doi.org/10.3390/ijms25031633

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