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Article

Characterization of HPMC and PEG 400 Mucoadhesive Film Loaded with Retinyl Palmitate and Ketorolac for Intravaginal Administration

by
Maryel E. Hernández-González
1,
Claudia A. Rodríguez-González
1,
Laura E. Valencia-Gómez
1,
Juan F. Hernández-Paz
1,
Florida Jiménez-Vega
2,
Mauricio Salcedo
3 and
Imelda Olivas-Armendáriz
1,*
1
Departamento de Física y Matemáticas, Instituto de Ingeniería y Tecnología, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez 32320, Mexico
2
Departamento de Ciencias Químico Biológicas, Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez 32315, Mexico
3
Unidad de Investigación Biomédica Oncológica Genómica, Hospital Gineco Pediatría 3-A, Instituto Mexicano del Seguro Social, Ciudad de México 07790, Mexico
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(23), 12692; https://doi.org/10.3390/ijms252312692
Submission received: 6 October 2024 / Revised: 18 November 2024 / Accepted: 22 November 2024 / Published: 26 November 2024
(This article belongs to the Special Issue Research on Synthesis and Application of Polymer Materials)
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Abstract

Intravaginal drug administration offers several advantages over other routes, primarily bypassing the initial stages of metabolism. Additionally, this route has demonstrated both local and systemic effects. Mucoadhesive polymeric systems can be utilized to prevent dose loss due to the mucous barriers and the formation of wet cavities. This study employed various techniques to evaluate the performance and characteristics of a mucoadhesive film composed of HPMC-PEG 400 containing retinyl palmitate and ketorolac molecules. Scanning Electron Microscopy (SEM) was employed to analyze the porous structure of the film. Thermogravimetric Analysis (TGA) was conducted at different temperatures to assess thermal stability. Fourier Transform Infrared Spectroscopy (FTIR) was used to analyze the functional groups and intermolecular interactions between the film and the drug. Swelling and weight loss tests indicated that the film disintegrated within 3–4 days. UV-VIS spectroscopy was used for drug release evaluation based on the Higuchi equation. Additionally, the surface wetting properties were assessed through contact angle measurements. The system’s biocompatibility was confirmed using the MTT assay. Finally, adhesion and glide tests demonstrated the film’s interaction with porcine uterine tissue. This study shows that the HPMC-PEG 400 film containing retinyl palmitate molecules interacts effectively with tissue and could be considered a novel tool for treating damaged epithelial tissues.
Keywords: HPMC; PEG 400; film; retinyl palmitate; intravaginal administration HPMC; PEG 400; film; retinyl palmitate; intravaginal administration

Share and Cite

MDPI and ACS Style

Hernández-González, M.E.; Rodríguez-González, C.A.; Valencia-Gómez, L.E.; Hernández-Paz, J.F.; Jiménez-Vega, F.; Salcedo, M.; Olivas-Armendáriz, I. Characterization of HPMC and PEG 400 Mucoadhesive Film Loaded with Retinyl Palmitate and Ketorolac for Intravaginal Administration. Int. J. Mol. Sci. 2024, 25, 12692. https://doi.org/10.3390/ijms252312692

AMA Style

Hernández-González ME, Rodríguez-González CA, Valencia-Gómez LE, Hernández-Paz JF, Jiménez-Vega F, Salcedo M, Olivas-Armendáriz I. Characterization of HPMC and PEG 400 Mucoadhesive Film Loaded with Retinyl Palmitate and Ketorolac for Intravaginal Administration. International Journal of Molecular Sciences. 2024; 25(23):12692. https://doi.org/10.3390/ijms252312692

Chicago/Turabian Style

Hernández-González, Maryel E., Claudia A. Rodríguez-González, Laura E. Valencia-Gómez, Juan F. Hernández-Paz, Florida Jiménez-Vega, Mauricio Salcedo, and Imelda Olivas-Armendáriz. 2024. "Characterization of HPMC and PEG 400 Mucoadhesive Film Loaded with Retinyl Palmitate and Ketorolac for Intravaginal Administration" International Journal of Molecular Sciences 25, no. 23: 12692. https://doi.org/10.3390/ijms252312692

APA Style

Hernández-González, M. E., Rodríguez-González, C. A., Valencia-Gómez, L. E., Hernández-Paz, J. F., Jiménez-Vega, F., Salcedo, M., & Olivas-Armendáriz, I. (2024). Characterization of HPMC and PEG 400 Mucoadhesive Film Loaded with Retinyl Palmitate and Ketorolac for Intravaginal Administration. International Journal of Molecular Sciences, 25(23), 12692. https://doi.org/10.3390/ijms252312692

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