Next Article in Journal
Identification and Analysis of Aluminum-Activated Malate Transporter Gene Family Reveals Functional Diversification in Orchidaceae and the Expression Patterns of Dendrobium catenatum Aluminum-Activated Malate Transporters
Next Article in Special Issue
Immunity and Coagulation in COVID-19
Previous Article in Journal
Evaluating the Dermatological Benefits of Snowberry (Symphoricarpos albus): A Comparative Analysis of Extracts and Fermented Products from Different Plant Parts
Previous Article in Special Issue
The Association of Genetic Markers Involved in Muscle Performance Responding to Lactate Levels during Physical Exercise Therapy by Nordic Walking in Patients with Long COVID Syndrome: A Nonrandomized Controlled Pilot Study
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 25
Issue 17
10.3390/ijms25179661
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Novel Clinical, Immunological, and Metabolic Features Associated with Persistent Post-Acute COVID-19 Syndrome

by
Karina Santana-de Anda
1,†,
Jiram Torres-Ruiz
1,†,
Nancy R. Mejía-Domínguez
2,
Beatriz Alcalá-Carmona
1,
José L. Maravillas-Montero
2,
José Carlos Páez-Franco
2,
Ana Sofía Vargas-Castro
3,
Jaquelin Lira-Luna
4,
Emmanuel A. Camacho-Morán
5,
Guillermo Juarez-Vega
2,
David Meza-Sánchez
2,
Carlos Núñez-Álvarez
1,
Marina Rull-Gabayet
1 and
Diana Gómez-Martín
1,2,*
1
Immunology and Rheumatology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico
2
Red de Apoyo a la Investigación, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico
3
Hospital Angeles Pedregal, Mexico City 10700, Mexico
4
Departamento de Cirugía General, Hospital Regional 1ro de Octubre, ISSSTE, Mexico City 07760, Mexico
5
Departamento de Medicina Crítica, Instituto Nacional de Perinatología, Isidro Espinosa de los Reyes, Mexico City 11000, Mexico
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(17), 9661; https://doi.org/10.3390/ijms25179661
Submission received: 12 August 2024 / Revised: 31 August 2024 / Accepted: 2 September 2024 / Published: 6 September 2024
(This article belongs to the Special Issue New Advances in Molecular Research of Coronavirus)
Browse Figures
Versions Notes

Abstract

The coronavirus disease 2019 (COVID-19) survivors are frequently observed to present persistent symptoms constituting what has been called “post-acute COVID-19 syndrome” (PACS) or “long COVID-19”. Some clinical risk factors have been identified to be associated with PACS development; however, specific mechanisms responsible for PACS pathology remain unknown. This study investigates clinical, immunological, and metabolomic risk factors associated with post-acute COVID-19 syndrome (PACS) in 51 patients, assessed 7–19 months after acute infection. Among the participants, 62.7% were male and 37.2% were female, with an average age of 47.8 years. At the follow-up, 37.2% met the criteria for PACS, revealing significant differences in immunological and metabolomic profiles at the time of acute infection. Patients with PACS were characterized by elevated levels of mature low-density granulocytes (LDGs), interleukin-8 (IL-8), pyruvate, pseudouridine, and cystine. Baseline multivariate analysis showed increased pyruvate and decreased alpha tocopherol levels. At follow-up, there was a decrease in absolute B lymphocytes and an increase in non-classical monocytes and 3-hydroxyisovaleric acid levels. These findings suggest that specific immunological and metabolomic markers during acute infection can help identify patients at higher risk of developing persistent PACS.
Keywords: persistent PACS; B cells; monocytes; neutrophils; chemokines; metabolomics persistent PACS; B cells; monocytes; neutrophils; chemokines; metabolomics

Share and Cite

MDPI and ACS Style

Santana-de Anda, K.; Torres-Ruiz, J.; Mejía-Domínguez, N.R.; Alcalá-Carmona, B.; Maravillas-Montero, J.L.; Páez-Franco, J.C.; Vargas-Castro, A.S.; Lira-Luna, J.; Camacho-Morán, E.A.; Juarez-Vega, G.; et al. Novel Clinical, Immunological, and Metabolic Features Associated with Persistent Post-Acute COVID-19 Syndrome. Int. J. Mol. Sci. 2024, 25, 9661. https://doi.org/10.3390/ijms25179661

AMA Style

Santana-de Anda K, Torres-Ruiz J, Mejía-Domínguez NR, Alcalá-Carmona B, Maravillas-Montero JL, Páez-Franco JC, Vargas-Castro AS, Lira-Luna J, Camacho-Morán EA, Juarez-Vega G, et al. Novel Clinical, Immunological, and Metabolic Features Associated with Persistent Post-Acute COVID-19 Syndrome. International Journal of Molecular Sciences. 2024; 25(17):9661. https://doi.org/10.3390/ijms25179661

Chicago/Turabian Style

Santana-de Anda, Karina, Jiram Torres-Ruiz, Nancy R. Mejía-Domínguez, Beatriz Alcalá-Carmona, José L. Maravillas-Montero, José Carlos Páez-Franco, Ana Sofía Vargas-Castro, Jaquelin Lira-Luna, Emmanuel A. Camacho-Morán, Guillermo Juarez-Vega, and et al. 2024. "Novel Clinical, Immunological, and Metabolic Features Associated with Persistent Post-Acute COVID-19 Syndrome" International Journal of Molecular Sciences 25, no. 17: 9661. https://doi.org/10.3390/ijms25179661

APA Style

Santana-de Anda, K., Torres-Ruiz, J., Mejía-Domínguez, N. R., Alcalá-Carmona, B., Maravillas-Montero, J. L., Páez-Franco, J. C., Vargas-Castro, A. S., Lira-Luna, J., Camacho-Morán, E. A., Juarez-Vega, G., Meza-Sánchez, D., Núñez-Álvarez, C., Rull-Gabayet, M., & Gómez-Martín, D. (2024). Novel Clinical, Immunological, and Metabolic Features Associated with Persistent Post-Acute COVID-19 Syndrome. International Journal of Molecular Sciences, 25(17), 9661. https://doi.org/10.3390/ijms25179661

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop