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Article

Use of Guazuma ulmifolia Lam. Stem Bark Extracts to Prevent High-Fat Diet Induced Metabolic Disorders in Mice

by
Elisana Lima Rodrigues
1,
Lidiani Figueiredo Santana
2,*,
Valter Aragão do Nascimento
1,
Marcel Asato Arakaki
3,
Claudia Andréa Lima Cardoso
4,
Wander Fernando de Oliveira Filiú
5,
Rita de Cássia Avellaneda Guimarães
1,
Priscila Aiko Hiane
1 and
Karine de Cássia Freitas
1
1
Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79070-900, MS, Brazil
2
Course of Medicine, State University of Mato Grosso do Sul, Campo Grande 79804-970, MS, Brazil
3
Medical School, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil
4
Course of Chemistry, State University of Mato Grosso do Sul, Dourados 79070-900, MS, Brazil
5
Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79079-900, MS, Brazil
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(16), 8889; https://doi.org/10.3390/ijms25168889
Submission received: 10 July 2024 / Revised: 5 August 2024 / Accepted: 10 August 2024 / Published: 15 August 2024
(This article belongs to the Special Issue Antioxidant, Anti-inflammatory, and Antiproliferative Activities of Natural Products—2nd Edition)
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Abstract

This study aimed to evaluate the effects of supplementation with ethanolic and aqueous extracts from the bark of the stem of Guazuma ulmifolia in mice submitted to a high-fat diet as well as to evaluate the chemical composition of these extracts. The chemical composition and antioxidant potential was evaluated in aqueous and ethanolic extracts of the stem bark. The in vivo test consisted of evaluating the effects of the aqueous and ethanolic extracts of the stem bark on C57BL/6 mice receiving a high-fat diet. The animals were evaluated for weight gain, feed consumption, visceral adiposity, serum, and inflammatory and hormonal parameters. The results of the chemical analyses corroborate those obtained by the literature, which reported gallocatechin, epigallocatechin and epigallocatechin gallate. Compared with the ethanolic extract, the aqueous extract showed greater antioxidant capacity. Both extracts resulted in lower feed consumption in the animals, but they did not influence weight gain or visceral adiposity and resulted in varied changes in the lipid profile. In addition, they did not influence glucose tolerance, insulin sensitivity, or fasting blood glucose. Furthermore, the leptin levels increased, which may have contributed to satiety, but this was shown to have a negative impact on other inflammatory and hormonal parameters. Therefore, under the conditions of this study, the biologically active compounds present in the plant species Guazuma ulmifolia were not able to contribute to the treatment of metabolic changes related to the consumption of a high-fat diet.
Keywords: antioxidants; high-fat diet; medicinal plants; phenolic compounds antioxidants; high-fat diet; medicinal plants; phenolic compounds

Share and Cite

MDPI and ACS Style

Rodrigues, E.L.; Santana, L.F.; Nascimento, V.A.d.; Arakaki, M.A.; Cardoso, C.A.L.; Filiú, W.F.d.O.; Guimarães, R.d.C.A.; Hiane, P.A.; Freitas, K.d.C. Use of Guazuma ulmifolia Lam. Stem Bark Extracts to Prevent High-Fat Diet Induced Metabolic Disorders in Mice. Int. J. Mol. Sci. 2024, 25, 8889. https://doi.org/10.3390/ijms25168889

AMA Style

Rodrigues EL, Santana LF, Nascimento VAd, Arakaki MA, Cardoso CAL, Filiú WFdO, Guimarães RdCA, Hiane PA, Freitas KdC. Use of Guazuma ulmifolia Lam. Stem Bark Extracts to Prevent High-Fat Diet Induced Metabolic Disorders in Mice. International Journal of Molecular Sciences. 2024; 25(16):8889. https://doi.org/10.3390/ijms25168889

Chicago/Turabian Style

Rodrigues, Elisana Lima, Lidiani Figueiredo Santana, Valter Aragão do Nascimento, Marcel Asato Arakaki, Claudia Andréa Lima Cardoso, Wander Fernando de Oliveira Filiú, Rita de Cássia Avellaneda Guimarães, Priscila Aiko Hiane, and Karine de Cássia Freitas. 2024. "Use of Guazuma ulmifolia Lam. Stem Bark Extracts to Prevent High-Fat Diet Induced Metabolic Disorders in Mice" International Journal of Molecular Sciences 25, no. 16: 8889. https://doi.org/10.3390/ijms25168889

APA Style

Rodrigues, E. L., Santana, L. F., Nascimento, V. A. d., Arakaki, M. A., Cardoso, C. A. L., Filiú, W. F. d. O., Guimarães, R. d. C. A., Hiane, P. A., & Freitas, K. d. C. (2024). Use of Guazuma ulmifolia Lam. Stem Bark Extracts to Prevent High-Fat Diet Induced Metabolic Disorders in Mice. International Journal of Molecular Sciences, 25(16), 8889. https://doi.org/10.3390/ijms25168889

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