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Article

Valpalf®: A New Nutraceutical Formulation Containing Bovine Lactoferrin That Exhibits Potentiated Biological Activity

by
Luigi Rosa
1,†,
Giusi Ianiro
2,†,
Antonella Niro
2,
Giovanni Musci
2,
Rosalba Paesano
3,
Antimo Cutone
2,* and
Piera Valenti
1,3
1
Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
2
Department of Biosciences and Territory, University of Molise, 86090 Pesche, Italy
3
Microbo s.r.l., 00153 Rome, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(16), 8559; https://doi.org/10.3390/ijms25168559
Submission received: 16 July 2024 / Revised: 31 July 2024 / Accepted: 4 August 2024 / Published: 6 August 2024
(This article belongs to the Special Issue New Insights into Lactoferrin)
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Abstract

As a nutraceutical, bovine lactoferrin (bLf), an iron-binding glycoprotein involved in innate immunity, is gaining elevated attention for its ability to exert pleiotropic functions and to be exceptionally tolerated even at high dosages. Some of bLf’s activities, including its anti-inflammatory and antioxidant, are tightly linked to its ability to both chelate iron and enter inside the cell nucleus. Here, we present data about Valpalf®, a new formulation containing bLf, sodium citrate, and sodium bicarbonate at a molar ratio of 10−3. In the present study, Valpalf® exhibits superior iron-binding capacity, resistance to tryptic digestion, and a greater capacity to accumulate into the nucleus over time when compared to the native bLf alone. In agreement, Valpalf® effectively reduces interleukin(IL)-6 levels in lipopolysaccharide-stimulated macrophages and modulates the expression of antioxidant enzymes, such as superoxide dismutase 1 and 2, in phorbol-12-myristate-13-acetate-stimulated monocytes. Of note, this potentiated bioactivity was corroborated in a retrospective study on the treatment of anemia of inflammation in hereditary thrombophilic pregnant and non-pregnant women, demonstrating that Valpalf® improves hematological parameters and reduces serum IL-6 levels to a higher extent than bLf alone.
Keywords: bovine lactoferrin; Valpalf®; iron chelation; proteolysis resistance; antioxidant activity; anti-inflammatory activity; anemia of inflammation bovine lactoferrin; Valpalf®; iron chelation; proteolysis resistance; antioxidant activity; anti-inflammatory activity; anemia of inflammation

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MDPI and ACS Style

Rosa, L.; Ianiro, G.; Niro, A.; Musci, G.; Paesano, R.; Cutone, A.; Valenti, P. Valpalf®: A New Nutraceutical Formulation Containing Bovine Lactoferrin That Exhibits Potentiated Biological Activity. Int. J. Mol. Sci. 2024, 25, 8559. https://doi.org/10.3390/ijms25168559

AMA Style

Rosa L, Ianiro G, Niro A, Musci G, Paesano R, Cutone A, Valenti P. Valpalf®: A New Nutraceutical Formulation Containing Bovine Lactoferrin That Exhibits Potentiated Biological Activity. International Journal of Molecular Sciences. 2024; 25(16):8559. https://doi.org/10.3390/ijms25168559

Chicago/Turabian Style

Rosa, Luigi, Giusi Ianiro, Antonella Niro, Giovanni Musci, Rosalba Paesano, Antimo Cutone, and Piera Valenti. 2024. "Valpalf®: A New Nutraceutical Formulation Containing Bovine Lactoferrin That Exhibits Potentiated Biological Activity" International Journal of Molecular Sciences 25, no. 16: 8559. https://doi.org/10.3390/ijms25168559

APA Style

Rosa, L., Ianiro, G., Niro, A., Musci, G., Paesano, R., Cutone, A., & Valenti, P. (2024). Valpalf®: A New Nutraceutical Formulation Containing Bovine Lactoferrin That Exhibits Potentiated Biological Activity. International Journal of Molecular Sciences, 25(16), 8559. https://doi.org/10.3390/ijms25168559

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