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Review

The Role of Muscarinic Acetylcholine Receptor M3 in Cardiovascular Diseases

by
Xinxing Liu
1,
Yi Yu
1,
Haiying Zhang
1,
Min Zhang
1,* and
Yan Liu
1,2,3,4,*
1
Hainan Academy of Medical Sciences, School of Pharmacy, Hainan Medical University, Haikou 571199, China
2
Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou 571199, China
3
International Joint Research Center of Human–Machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou 571199, China
4
Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou 571199, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(14), 7560; https://doi.org/10.3390/ijms25147560
Submission received: 22 May 2024 / Revised: 4 July 2024 / Accepted: 5 July 2024 / Published: 10 July 2024
(This article belongs to the Special Issue Translational Medicine of Vascular and Lymphatic Diseases: From the Molecule to the Clinic)
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Abstract

The muscarinic acetylcholine receptor M3 (M3-mAChR) is involved in various physiological and pathological processes. Owing to specific cardioprotective effects, M3-mAChR is an ideal diagnostic and therapeutic biomarker for cardiovascular diseases (CVDs). Growing evidence has linked M3-mAChR to the development of multiple CVDs, in which it plays a role in cardiac protection such as anti-arrhythmia, anti-hypertrophy, and anti-fibrosis. This review summarizes M3-mAChR’s expression patterns, functions, and underlying mechanisms of action in CVDs, especially in ischemia/reperfusion injury, cardiac hypertrophy, and heart failure, opening up a new research direction for the treatment of CVDs.
Keywords: muscarinic acetylcholine receptor M3; cardiomyocyte; endothelial cell; fibroblast; cardiovascular diseases muscarinic acetylcholine receptor M3; cardiomyocyte; endothelial cell; fibroblast; cardiovascular diseases

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MDPI and ACS Style

Liu, X.; Yu, Y.; Zhang, H.; Zhang, M.; Liu, Y. The Role of Muscarinic Acetylcholine Receptor M3 in Cardiovascular Diseases. Int. J. Mol. Sci. 2024, 25, 7560. https://doi.org/10.3390/ijms25147560

AMA Style

Liu X, Yu Y, Zhang H, Zhang M, Liu Y. The Role of Muscarinic Acetylcholine Receptor M3 in Cardiovascular Diseases. International Journal of Molecular Sciences. 2024; 25(14):7560. https://doi.org/10.3390/ijms25147560

Chicago/Turabian Style

Liu, Xinxing, Yi Yu, Haiying Zhang, Min Zhang, and Yan Liu. 2024. "The Role of Muscarinic Acetylcholine Receptor M3 in Cardiovascular Diseases" International Journal of Molecular Sciences 25, no. 14: 7560. https://doi.org/10.3390/ijms25147560

APA Style

Liu, X., Yu, Y., Zhang, H., Zhang, M., & Liu, Y. (2024). The Role of Muscarinic Acetylcholine Receptor M3 in Cardiovascular Diseases. International Journal of Molecular Sciences, 25(14), 7560. https://doi.org/10.3390/ijms25147560

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