Recent Developments in the Inhibition of Bacterial Adhesion as Promising Anti-Virulence Strategy
Abstract
:1. Introduction
2. Adhesion Proteins as Promising Targets for Preventing Antibiotic Resistance
3. Recent Developments of Anti-Adhesion Agents against Relevant Pathogens
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Proteins | Functions | Role in Pathogenesis |
---|---|---|
Protein A (Spa) | Binds Fc domain for immunoglobulins; binds complement protein C3 | Inhibition of innate and adaptive immune responses |
Fibronectin-binding protein A (FnbpA) | Adhesin for fibrinogen, fibronectin and elastin | Adhesion; colonization; biofilm formation |
Fibronectin-binding protein homolog (FnbpB) | Adhesin for fibronectin and elastin | Adhesion; colonization; biofilm formation |
Clumping factor A (ClfA) | Platelet adhesion (fibrin-mediated) | Adhesion; colonization; evasion of innate immune defenses |
Clumping factor B (ClfB) | Platelet adhesion (fibrin-mediated) | Adhesion; colonization; evasion of innate immune defenses |
Collagen-binding protein (Cna) | Adhesin for collagen (type I and IV) | Adhesion |
Serine-aspartate repeat protein C (SdrC) | Adhesin | Adhesion; colonization |
Serine-aspartate repeat protein D (SdrD) | Adhesin | Adhesion; colonization |
Serine-aspartate repeat protein E (SdrE) | Adhesin | Adhesion; colonization |
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Pecoraro, C.; Carbone, D.; Parrino, B.; Cascioferro, S.; Diana, P. Recent Developments in the Inhibition of Bacterial Adhesion as Promising Anti-Virulence Strategy. Int. J. Mol. Sci. 2023, 24, 4872. https://doi.org/10.3390/ijms24054872
Pecoraro C, Carbone D, Parrino B, Cascioferro S, Diana P. Recent Developments in the Inhibition of Bacterial Adhesion as Promising Anti-Virulence Strategy. International Journal of Molecular Sciences. 2023; 24(5):4872. https://doi.org/10.3390/ijms24054872
Chicago/Turabian StylePecoraro, Camilla, Daniela Carbone, Barbara Parrino, Stella Cascioferro, and Patrizia Diana. 2023. "Recent Developments in the Inhibition of Bacterial Adhesion as Promising Anti-Virulence Strategy" International Journal of Molecular Sciences 24, no. 5: 4872. https://doi.org/10.3390/ijms24054872