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Article

Altered Differential Expression of Genes and microRNAs Related to Adhesion and Apoptosis Pathways in Patients with Different Phenotypes of Endometriosis

by
Luana Grupioni Lourenço Antonio
,
Juliana Meola
,
Ana Carolina Japur de Sá Rosa-e-Silva
,
Antonio Alberto Nogueira
,
Francisco José Candido dos Reis
,
Omero Benedicto Poli-Neto
and
Julio César Rosa-e-Silva
*
Ribeirão Preto Medical School, University of São Paulo, 3900 Bandeirantes Av., Ribeirão Preto 14049-900, SP, Brazil
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(5), 4434; https://doi.org/10.3390/ijms24054434
Submission received: 22 January 2023 / Revised: 13 February 2023 / Accepted: 13 February 2023 / Published: 23 February 2023
(This article belongs to the Special Issue Molecular and Cellular Advances in Endometriosis Research 2.0)
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Abstract

We aim to investigate the expression of genes (MAPK1 and CAPN2) and microRNAs (miR-30a-5p, miR-7-5p, miR-143-3p, and miR-93-5p) involved in adhesion and apoptosis pathways in superficial peritoneal endometriosis (SE), deep infiltrating endometriosis (DE), and ovarian endometrioma (OE), and to evaluate whether these lesions share the same pathophysiological mechanisms. We used samples of SE (n = 10), DE (n = 10), and OE (n = 10), and endometrial biopsies of these respective patients affected with endometriosis under treatment at a tertiary University Hospital. Endometrial biopsies collected in the tubal ligation procedure from women without endometriosis comprised the control group (n = 10). Quantitative real-time polymerase chain reaction was performed. The expression of MAPK1 (p < 0.0001), miR-93-5p (p = 0.0168), and miR-7-5p (p = 0.0006) was significantly lower in the SE group than in the DE and OE groups. The expression of miR-30a (p = 0.0018) and miR-93 (p = 0.0052) was significantly upregulated in the eutopic endometrium of women with endometriosis compared to the controls. MiR-143 (p = 0.0225) expression also showed a statistical difference between the eutopic endometrium of women with endometriosis and the control group. In summary, SE showed lower pro-survival gene expression and miRNAs involved in this pathway, indicating that this phenotype has a different pathophysiological mechanism compared to DE and OE.
Keywords: endometriosis; genes; microRNAs; MAPK1; CAPN2 endometriosis; genes; microRNAs; MAPK1; CAPN2

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MDPI and ACS Style

Antonio, L.G.L.; Meola, J.; Rosa-e-Silva, A.C.J.d.S.; Nogueira, A.A.; Candido dos Reis, F.J.; Poli-Neto, O.B.; Rosa-e-Silva, J.C. Altered Differential Expression of Genes and microRNAs Related to Adhesion and Apoptosis Pathways in Patients with Different Phenotypes of Endometriosis. Int. J. Mol. Sci. 2023, 24, 4434. https://doi.org/10.3390/ijms24054434

AMA Style

Antonio LGL, Meola J, Rosa-e-Silva ACJdS, Nogueira AA, Candido dos Reis FJ, Poli-Neto OB, Rosa-e-Silva JC. Altered Differential Expression of Genes and microRNAs Related to Adhesion and Apoptosis Pathways in Patients with Different Phenotypes of Endometriosis. International Journal of Molecular Sciences. 2023; 24(5):4434. https://doi.org/10.3390/ijms24054434

Chicago/Turabian Style

Antonio, Luana Grupioni Lourenço, Juliana Meola, Ana Carolina Japur de Sá Rosa-e-Silva, Antonio Alberto Nogueira, Francisco José Candido dos Reis, Omero Benedicto Poli-Neto, and Julio César Rosa-e-Silva. 2023. "Altered Differential Expression of Genes and microRNAs Related to Adhesion and Apoptosis Pathways in Patients with Different Phenotypes of Endometriosis" International Journal of Molecular Sciences 24, no. 5: 4434. https://doi.org/10.3390/ijms24054434

APA Style

Antonio, L. G. L., Meola, J., Rosa-e-Silva, A. C. J. d. S., Nogueira, A. A., Candido dos Reis, F. J., Poli-Neto, O. B., & Rosa-e-Silva, J. C. (2023). Altered Differential Expression of Genes and microRNAs Related to Adhesion and Apoptosis Pathways in Patients with Different Phenotypes of Endometriosis. International Journal of Molecular Sciences, 24(5), 4434. https://doi.org/10.3390/ijms24054434

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