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Volume 24
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Review

Irreversible Electroporation in Pancreatic Cancer—An Evolving Experimental and Clinical Method

by
Agnieszka Gajewska-Naryniecka
1,
Urszula Szwedowicz
1,
Zofia Łapińska
1,
Julia Rudno-Rudzińska
2,
Wojciech Kielan
2 and
Julita Kulbacka
1,3,*
1
Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland
2
2nd Department of General Surgery and Surgical Oncology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland
3
Department of Immunology, State Research Institute Centre for Innovative Medicine, Santariškių 5, 08410 Vilnius, Lithuania
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(5), 4381; https://doi.org/10.3390/ijms24054381
Submission received: 11 January 2023 / Revised: 13 February 2023 / Accepted: 20 February 2023 / Published: 23 February 2023
(This article belongs to the Special Issue Targeted Therapies and Molecular Methods in Cancer)
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Abstract

Pancreatic cancer has no symptoms until the disease has advanced and is aggressive cancer with early metastasis. Up to now, the only curative treatment is surgical resection, which is possible in the early stages of the disease. Irreversible electroporation treatment offers new hope for patients with unresectable tumors. Irreversible electroporation (IRE) is a type of ablation therapy that has been explored as a potential treatment for pancreatic cancer. Ablation therapies involve the use of energy to destroy or damage cancer cells. IRE involves using high-voltage, low-energy electrical pulses to create resealing in the cell membrane, causing the cell to die. This review summarizes experiential and clinical findings in terms of the IRE applications. As was described, IRE can be a non-pharmacological approach (electroporation) or combined with anticancer drugs or standard treatment methods. The efficacy of irreversible electroporation (IRE) in eliminating pancreatic cancer cells has been demonstrated through both in vitro and in vivo studies, and it has been shown to induce an immune response. Nevertheless, further investigation is required to assess its effectiveness in human subjects and to comprehensively understand IRE’s potential as a treatment option for pancreatic cancer.
Keywords: pancreatic cancer; irreversible electroporation; immune response pancreatic cancer; irreversible electroporation; immune response

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MDPI and ACS Style

Gajewska-Naryniecka, A.; Szwedowicz, U.; Łapińska, Z.; Rudno-Rudzińska, J.; Kielan, W.; Kulbacka, J. Irreversible Electroporation in Pancreatic Cancer—An Evolving Experimental and Clinical Method. Int. J. Mol. Sci. 2023, 24, 4381. https://doi.org/10.3390/ijms24054381

AMA Style

Gajewska-Naryniecka A, Szwedowicz U, Łapińska Z, Rudno-Rudzińska J, Kielan W, Kulbacka J. Irreversible Electroporation in Pancreatic Cancer—An Evolving Experimental and Clinical Method. International Journal of Molecular Sciences. 2023; 24(5):4381. https://doi.org/10.3390/ijms24054381

Chicago/Turabian Style

Gajewska-Naryniecka, Agnieszka, Urszula Szwedowicz, Zofia Łapińska, Julia Rudno-Rudzińska, Wojciech Kielan, and Julita Kulbacka. 2023. "Irreversible Electroporation in Pancreatic Cancer—An Evolving Experimental and Clinical Method" International Journal of Molecular Sciences 24, no. 5: 4381. https://doi.org/10.3390/ijms24054381

APA Style

Gajewska-Naryniecka, A., Szwedowicz, U., Łapińska, Z., Rudno-Rudzińska, J., Kielan, W., & Kulbacka, J. (2023). Irreversible Electroporation in Pancreatic Cancer—An Evolving Experimental and Clinical Method. International Journal of Molecular Sciences, 24(5), 4381. https://doi.org/10.3390/ijms24054381

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